Everything about PTPRH

🧭 Start here: a 6-step reading path

1. Read the overview: PTPRHA 5-minute orientation
2. Skim a recent paper: Functional impact assessment of tissue-specific missense variants in the PTPRH gene using a multi-tool computational frameworkInfluential work since 2022
3. Read the landmark paper: PTPRH promotes the progression of non-small cell lung cancer via glycolysis mediated by the PI3K/AKT/mTOR signaling pathwayCited 48 times
4. Go sideways: PTPRFA closely related topic
5. Go sideways: PTPRN2A closely related topic

🏆 Landmark papers (most cited)

• PTPRH promotes the progression of non-small cell lung cancer via glycolysis mediated by the PI3K/AKT/mTOR signaling pathway

  Shu Wang, Zhiming Cheng, Yan Cui · 2023 · Journal of Translational Medicine · 48 citations

• Sap-1/PTPRH activity is regulated by reversible dimerization

  Sébastien Wälchli, Xavier Espanel, Rob Hooft van Huijsduijnen · 2005 · Biochemical and Biophysical Research Communications · 30 citations

• Prognostic implication of PTPRH hypomethylation in non-small cell lung cancer

  TAKASHI SATO, KENZO SOEJIMA, ERI ARAI · 2015 · Oncology Reports · 26 citations

• Elevated phosphorylation of EGFR in NSCLC due to mutations in PTPRH

  Matthew R. Swiatnicki, Jonathan P. Rennhack, Mylena M. O. Ortiz · 2022 · PLOS Genetics · 15 citations

• Downregulation of PTPRH (Sap-1) in colorectal tumors

  Mateusz Bujko, Paulina Kober, Małgorzata Statkiewicz · 2017 · International Journal of Oncology · 9 citations

• The High Expression of PTPRH Is Associated with Poor Prognosis of Human Lung Adenocarcinoma

  Aifeng Chen, Shibiao Ding, Xiaoqiang Shen · 2021 · Computational and Mathematical Methods in Medicine · 5 citations

• Gene for the human transmembrane-type protein tyrosine phosphatase H (PTPRH): genomic structure, fine-mapping and its exclusion as a candidate for Peutz-Jeghers syndrome

  A.G. Marneros, H. Mehenni, E. Reichenberger · 2001 · Cytogenetic and Genome Research · 5 citations

• PTPRH Alleviates Airway Obstruction and Th2 Inflammation in Asthma as a Protective Factor

  Feng-jia Chen, Li-juan Du, Zhimin Zeng · 2022 · Journal of Asthma and Allergy · 4 citations

🆕 Influential since 2022

• Functional impact assessment of tissue-specific missense variants in the PTPRH gene using a multi-tool computational framework

  Ali Ammar Naseem, Ranjha Khan, Uzma Hameed · 2026 · Cancer Genetics · 0 citations

• RBM15/IGF2BP2–PTPRH m6A regulatory axis in non-small cell lung cancer

  Keyue Qiu, Xiaoxiao Zheng, Hongxiang Li · 2026 · Cellular Oncology · 0 citations

• Abstract 3296: The receptor-like protein tyrosine phosphatase PTPRH modulates dephosphorylation of the tyrosine kinases EPHA2 and EGFR, alters cell morphology and adhesion, and behaves as a tumor-suppressor in non-small cell lung cancer cell

  Mylena Ortiz, Deeya Patel, Jesus Garcia-Lerena · 2026 · Cancer Research · 0 citations

📚 Books worth reading

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🔗 Related topics

• PTPRF Receptor-type tyrosine-protein phosphatase F is an enzyme that, in humans, is encoded by the PTPRF gene. The protein encoded by this gene is a member of…
• PTPRN2 Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) also known as islet cell autoantigen-related protein (ICAAR) and phogrin is an enzyme that in…
• PTPRS Receptor-type tyrosine-protein phosphatase S, also known as R-PTP-S, R-PTP-sigma, or PTPσ, is an enzyme that in humans is encoded by the PTPRS gene. The…
• PTPRJ Receptor-type tyrosine-protein phosphatase eta is an enzyme that in humans is encoded by the PTPRJ gene. The protein encoded by this gene is a member of…
• PTPN2 Tyrosine-protein phosphatase non-receptor type 2 is an enzyme that in humans is encoded by the PTPN2 gene. The protein encoded by this gene is a member…
• PTPRG Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the PTPRG gene. The protein encoded by this gene is a member…
• PTPRD Receptor-type tyrosine-protein phosphatase delta is an enzyme that, in humans, is encoded by the PTPRD gene. The protein encoded by this gene is a member…
• PTPRE Receptor-type tyrosine-protein phosphatase epsilon is an enzyme that in humans is encoded by the PTPRE gene. The protein encoded by this gene is a member…