Everything about PTPN2

🧭 Start here: a 6-step reading path

1. Read the overview: PTPN2A 5-minute orientation
2. Skim a recent paper: A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunityInfluential work since 2022
3. Read the landmark paper: In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy targetCited 1,108 times
4. Go sideways: PTPN1A closely related topic
5. Go sideways: PTPN3A closely related topic

🏆 Landmark papers (most cited)

• In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

  Robert T. Manguso, Hans W. Pope, Margaret D. Zimmer · 2017 · Nature · 1,108 citations

• PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity

  Martin W. LaFleur, Thao H. Nguyen, Matthew A. Coxe · 2019 · Nature Immunology · 241 citations

• The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

  Christina K. Baumgartner, Hakimeh Ebrahimi-Nik, Arvin Iracheta-Vellve · 2023 · Nature · 200 citations

• A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease

  Eleonora A. M. Festen, Philippe Goyette, Todd Green · 2011 · PLoS Genetics · 199 citations

• Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia

  Maria Kleppe, Idoya Lahortiga, Tiama El Chaar · 2010 · Nature Genetics · 171 citations

• PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis

  Fabrice Moore, Maikel L. Colli, Miriam Cnop · 2009 · Diabetes · 159 citations

• PTPN2 Regulates Interactions Between Macrophages and Intestinal Epithelial Cells to Promote Intestinal Barrier Function

  Marianne R. Spalinger, Anica Sayoc-Becerra, Alina N. Santos · 2020 · Gastroenterology · 149 citations

• PTPN2 phosphatase deletion in T cells promotes anti‐tumour immunity and CAR T‐cell efficacy in solid tumours

  Florian Wiede, Kun‐Hui Lu, Xin Du · 2019 · The EMBO Journal · 140 citations

🆕 Influential since 2022

• A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity

  Shuwei Liang, Eric Tran, Xin Du · 2023 · Nature Communications · 94 citations

• Matrine suppresses NLRP3 inflammasome activation via regulating PTPN2/JNK/SREBP2 pathway in sepsis

  Xu Wang, Fu-Peng Wu, Yu-Ran Huang · 2023 · Phytomedicine · 61 citations

• PTPN2 elicits cell autonomous and non–cell autonomous effects on antitumor immunity in triple-negative breast cancer

  Pei Kee Goh, Florian Wiede, Mara N. Zeissig · 2022 · Science Advances · 52 citations

• PTPN2 in the Immunity and Tumor Immunotherapy: A Concise Review

  Jiachun Song, Jinxin Lan, Jiaping Tang · 2022 · International Journal of Molecular Sciences · 39 citations

• Haploinsufficiency in PTPN2 leads to early-onset systemic autoimmunity from Evans syndrome to lupus

  Marie Jeanpierre, Jade Cognard, Maud Tusseau · 2024 · Journal of Experimental Medicine · 36 citations

📚 Books worth reading

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🔗 Related topics

• PTPN1 Tyrosine-protein phosphatase non-receptor type 1 also known as protein-tyrosine phosphatase 1B (PTP1B) is an enzyme that is the founding member of the…
• PTPN3 Tyrosine-protein phosphatase non-receptor type 3 is an enzyme that in humans is encoded by the PTPN3 gene. The protein encoded by this gene is a member…
• PTPRH Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the PTPRH gene. The protein encoded by this gene is a member of…
• PTPRF Receptor-type tyrosine-protein phosphatase F is an enzyme that, in humans, is encoded by the PTPRF gene. The protein encoded by this gene is a member of…
• PTPN12 Tyrosine-protein phosphatase non-receptor type 12 is an enzyme that in humans is encoded by the PTPN12 gene. The protein encoded by this gene is a member…
• PTPRN2 Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) also known as islet cell autoantigen-related protein (ICAAR) and phogrin is an enzyme that in…
• PTPN9 Tyrosine-protein phosphatase non-receptor type 9 is an enzyme that in humans is encoded by the PTPN9 gene. The protein encoded by this gene is a member…
• PTPN4 Tyrosine-protein phosphatase non-receptor type 4 is an enzyme that in humans is encoded by the PTPN4 gene. The protein encoded by this gene is a member…