Everything about PTPRD

🧭 Start here: a 6-step reading path

1. Read the overview: PTPRDA 5-minute orientation
2. Skim a recent paper: Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCγ1 axisInfluential work since 2022
3. Read the landmark paper: The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancersCited 249 times
4. Go sideways: PTPRSA closely related topic
5. Go sideways: PTPRFA closely related topic

🏆 Landmark papers (most cited)

• The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers

  Selvaraju Veeriah, Cameron Brennan, Shasha Meng · 2009 · Proceedings of the National Academy of Sciences · 249 citations

• PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome

  Barbara Schormair, David Kemlink, Darina Roeske · 2008 · Nature Genetics · 241 citations

• Periodic Leg Movements during Sleep Are Associated with Polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD

  Hyatt Moore, Juliane Winkelmann, Ling Lin · 2014 · Sleep · 112 citations

• Mutational Inactivation of PTPRD in Glioblastoma Multiforme and Malignant Melanoma

  David A. Solomon, Jung-Sik Kim, Julia C. Cronin · 2008 · Cancer Research · 110 citations

• High-Resolution Analysis of Chromosomal Breakpoints and Genomic Instability Identifies PTPRD as a Candidate Tumor Suppressor Gene in Neuroblastoma

  Raymond L. Stallings, Prakash Nair, John M. Maris · 2006 · Cancer Research · 99 citations

• Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis

  Berenice Ortiz, Armida W. M. Fabius, Wei H. Wu · 2014 · Proceedings of the National Academy of Sciences · 93 citations

• PTPRD: neurobiology, genetics, and initial pharmacology of a pleiotropic contributor to brain phenotypes

  George R. Uhl, Maria J. Martinez · 2019 · Annals of the New York Academy of Sciences · 90 citations

• Susceptibility to neurofibrillary tangles: role of the PTPRD locus and limited pleiotropy with other neuropathologies

  L B Chibnik, C C White, S Mukherjee · 2017 · Molecular Psychiatry · 77 citations

🆕 Influential since 2022

• Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCγ1 axis

  Junhua Xu, Yanfeng Zhong, Haoyang Yin · 2022 · Journal of Hypertension · 22 citations

• PTPRD and CNTNAP2 as markers of tumor aggressiveness in oligodendrogliomas

  Kirsi J. Rautajoki, Serafiina Jaatinen, Aliisa M. Tiihonen · 2022 · Scientific Reports · 19 citations

• PTPRD/PTPRT mutation as a predictive biomarker of immune checkpoint inhibitors across multiple cancer types

  Xiaoling Shang, Wengang Zhang, Xun Zhang · 2022 · Frontiers in Immunology · 16 citations

• Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice

  Bastián I. Cortés, Rodrigo C. Meza, Carlos Ancatén-González · 2024 · Biological Research · 14 citations

• PTPRD and DCC Are Novel BACE1 Substrates Differentially Expressed in Alzheimer’s Disease: A Data Mining and Bioinformatics Study

  Hannah A. Taylor, Katie J. Simmons, Eva M. Clavane · 2022 · International Journal of Molecular Sciences · 13 citations

📚 Books worth reading

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🔗 Related topics

• PTPRS Receptor-type tyrosine-protein phosphatase S, also known as R-PTP-S, R-PTP-sigma, or PTPσ, is an enzyme that in humans is encoded by the PTPRS gene. The…
• PTPRF Receptor-type tyrosine-protein phosphatase F is an enzyme that, in humans, is encoded by the PTPRF gene. The protein encoded by this gene is a member of…
• Liprin-alpha-1 Liprin-alpha-1 is a protein that in humans is encoded by the PPFIA1 gene. The protein encoded by this gene is a member of the LAR protein tyrosine pho…
• PTPRE Receptor-type tyrosine-protein phosphatase epsilon is an enzyme that in humans is encoded by the PTPRE gene. The protein encoded by this gene is a member…
• PTPRG Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the PTPRG gene. The protein encoded by this gene is a member…
• PTPRU Receptor-type tyrosine-protein phosphatase PCP-2 (also known as PTP-pi, PTP lambda, hPTP-J, PTPRO and PTP psi), is an enzyme that in humans is encoded…
• PTPRZ1 Receptor-type tyrosine-protein phosphatase zeta also known as phosphacan is an enzyme that in humans is encoded by the PTPRZ1 gene (previously PTPRZ).…
• PTPRM Receptor-type tyrosine-protein phosphatase mu is an enzyme that in humans is encoded by the PTPRM gene. The protein encoded by this gene is a member of…