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Everything about Genomics

Discipline in genetics

Genomics is an interdisciplinary field of molecular biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dimensional structural configuration. In contrast to genetics, which refers to the study of individual genes and their roles in inheritance, genomics aims at the collective characterization and quantification of all of an organism's genes, their interrelations and influence on the organism. Genes may direct the production of proteins with the assistance of enzymes and messenger molecules. In turn, proteins make up body structures such as organs and tissues as well as control chemical reactions and carry signals between cells. Genomics also involves the sequencing and analysis of genomes through uses of high throughput DNA sequencing and bioinformatics to assemble and analyze the function and structure of entire genomes. Advances in genomics have triggered a revolution in discovery-based research and systems biology to facilitate understanding of even the most complex biological systems such as the brain. Wikipedia →

🧭 Start here: a 6-step reading path

  1. Read the overview: GenomicsA 5-minute orientation
  2. Skim a recent paper: Omicron variant of SARS‐CoV‐2: Genomics, transmissibility, and responses to current COVID‐19 vaccinesInfluential work since 2022
  3. Pick up a classic book: Advances in geneticsThe most-reprinted book on the subject
  4. Read the landmark paper: Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular PathologyCited 30,803 times
  5. Go sideways: Molecular geneticsA closely related topic
  6. Go sideways: BioinformaticsA closely related topic

📖 Definitions

Noun The study of the complete genome of an organism.

🗂️ The subject at a glance

  1. History
  2. Genome analysis
  3. Research areas
  4. Applications

🏆 Landmark papers (most cited)

🆕 Influential since 2022

📚 Books worth reading

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics