Everything about SCN2B

🧭 Start here: a 6-step reading path

1. Read the overview: SCN2BA 5-minute orientation
2. Skim a recent paper: SCN2B drives depression-like phenotypes in mice by suppressing BDNF signaling via its intracellular domain NICDInfluential work since 2022
3. Pick up a classic book: Melatonin after four decadesThe most-reprinted book on the subject
4. Read the landmark paper: A Missense Mutation in the Sodium Channel β2 Subunit RevealsSCN2Bas a New Candidate Gene for Brugada SyndromeCited 101 times
5. Go sideways: SCN3BA closely related topic
6. Go sideways: SCN1BA closely related topic

🏆 Landmark papers (most cited)

• A Missense Mutation in the Sodium Channel β2 Subunit RevealsSCN2Bas a New Candidate Gene for Brugada Syndrome

  Helena Riuró, Pedro Beltran-Alvarez, Anna Tarradas · 2013 · Human Mutation · 101 citations

• Scn2b Deletion in Mice Results in Ventricular and Atrial Arrhythmias

  Yangyang Bao, B. Cicero Willis, Chad R. Frasier · 2016 · Circulation: Arrhythmia and Electrophysiology · 49 citations

• Case–control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy

  Larry Baum, Batoul Sadat Haerian, Ho-Keung Ng · 2013 · Human Genetics · 33 citations

• Post-transcriptional silencing of SCN1B and SCN2B genes modulates late sodium current in cardiac myocytes from normal dogs and dogs with chronic heart failure

  Sudhish Mishra, Nidas A. Undrovinas, Victor A. Maltsev · 2011 · American Journal of Physiology-Heart and Circulatory Physiology · 31 citations

• SCN1B and SCN2B gene variants analysis in dravet syndrome patients

  Jiao-E. Gong, Hong-Mei Liao, Hong-Yu Long · 2019 · Medicine · 15 citations

• SCN2B in the Rat Trigeminal Ganglion and Trigeminal Sensory Nuclei

  Yusuke Shimada, Tadasu Sato, Takehiro Yajima · 2016 · Cellular and Molecular Neurobiology · 11 citations

• Scn2b,a Voltage-Gated Sodium Channel β2 Gene on Mouse Chromosome 9

  J.M. Jones, M.H. Meisler, L.L. Isom · 1996 · Genomics · 11 citations

• MicroRNA‑449a regulates the progression of brain aging by targeting SCN2B in SAMP8 mice

  Ya‑Xin Tan, Ying Hong, Shui Jiang · 2020 · International Journal of Molecular Medicine · 7 citations

🆕 Influential since 2022

• SCN2B drives depression-like phenotypes in mice by suppressing BDNF signaling via its intracellular domain NICD

  Min-Nan Lu, Guo-Ji Yan, Dan Wang · 2027 · Neuropharmacology · 0 citations

• A novel homozygous SCN2B variant associated with early-onset developmental and epileptic encephalopathy in two siblings

  Ayberk Selek, Sebahattin Vurucu, Bülent Unay · 2026 · Seizure: European Journal of Epilepsy · 0 citations

📚 Books worth reading

• Melatonin after four decadesJames Olcese · 1999
• 📕Untersuchung der Kandidatengene GABRG2 und SCN1B bei Fieberkrämpfen des KindesaltersHeike Christina Pfeiffer · 2004
• 📕Strukturelle und kristallphysikalische Charakterisierung der komplexen Thiosulfate vom Typ A₉[B(S₂O₃)₄]X₂Peter Held · 1994

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics

• SCN3B Sodium channel subunit beta-3 is a protein that in humans is encoded by the SCN3B gene. Two alternatively spliced variants, encoding the same protein,…
• SCN1B Sodium channel subunit beta-1 is a protein that in humans is encoded by the SCN1B gene. Voltage-gated sodium channels are essential for the generation…
• CHRNB2 Neuronal acetylcholine receptor subunit beta-2 is a protein that in humans is encoded by the CHRNB2 gene. Neuronal acetylcholine receptors are homo- or…
• KCNMB2 Calcium-activated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNMB2 gene. Big Potassium (BK) channels are large conductance…
• CHRNB1 Acetylcholine receptor subunit beta is a protein that in humans is encoded by the CHRNB1 gene. The muscle acetylcholine receptor is composed of five subunits:…
• AP4B1 AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene. The heterotetrameric adaptor protein (AP) complexes sort integral…
• SCN4B Sodium channel β-subunit 4, also known as SCN4B or Naβ4, is an auxiliary sodium channel subunit that can alter the kinetics of sodium channels. The protein…
• HCN3 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 is a protein that in humans is encoded by the HCN3 gene. Cyclic nucleotide–gated…