Live briefing
Everything about SCN1B
Protein-coding gene in the species Homo sapiens
Sodium channel subunit beta-1 is a protein that in humans is encoded by the SCN1B gene. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: SCN1BA 5-minute orientation
- Skim a recent paper: Neonatal Scn1b-null mice have sinoatrial node dysfunction, altered atrial structure, and atrial fibrillationInfluential work since 2022
- Pick up a classic book: Melatonin after four decadesThe most-reprinted book on the subject
- Read the landmark paper: Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel ß1 subunit gene SCN1BCited 621 times
- Go sideways: SCN1AA closely related topic
- Go sideways: Generalized epilepsy with febrile seizures plusA closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel ß1 subunit gene SCN1B
A Functional Null Mutation ofSCN1Bin a Patient with Dravet Syndrome
Temporal lobe epilepsy and GEFS+ phenotypes associated with SCN1B mutations
A deletion in SCN1B is associated with febrile seizures and early-onset absence epilepsy
Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals
Generalized epilepsy with febrile seizures plus: Mutation of the sodium channel subunit SCN1B
A homozygous mutation of voltage‐gated sodium channel β I gene SCN1B in a patient with Dravet syndrome
Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b -null mice and precedes hyperexcitability
🆕 Influential since 2022
Neonatal Scn1b-null mice have sinoatrial node dysfunction, altered atrial structure, and atrial fibrillation
SCN1B Genetic Variants: A Review of the Spectrum of Clinical Phenotypes and a Report of Early Myoclonic Encephalopathy
Epilepsy and sudden unexpected death in epilepsy in a mouse model of human SCN1B-linked developmental and epileptic encephalopathy
Scn1b expression in the adult mouse heart modulates Na+ influx in myocytes and reveals a mechanistic link between Na+ entry and diastolic function
Neonatal but not juvenile gene therapy reduces seizures and prolongs lifespan in SCN1B–Dravet syndrome mice
📚 Books worth reading
Melatonin after four decadesJames Olcese · 1999- 📕Molekulargenetische Untersuchungen zur Rolle der antriumkanaluntereinheit SCN1B bei idiopathischen EpilepsienJörn Stefan Dullinger · 2006
- 📕Untersuchung der Kandidatengene GABRG2 und SCN1B bei Fieberkrämpfen des KindesaltersHeike Christina Pfeiffer · 2004
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- SCN1A Sodium channel protein type 1 subunit alpha (SCN1A), is a protein which in humans is encoded by the SCN1A gene. The SCN1A gene is located on chromosome…
- Generalized epilepsy with febrile seizures plus Generalized epilepsy with febrile seizures plus (GEFS+) is a syndromic autosomal dominant disorder where affected individuals can exhibit numerous epilepsy…
- SCN2A Sodium channel protein type 2 subunit alpha, also known as Nav1.2, is an ion channel protein encoded by the SCN2A gene in humans. It represents one member…
- SCN4B Sodium channel β-subunit 4, also known as SCN4B or Naβ4, is an auxiliary sodium channel subunit that can alter the kinetics of sodium channels. The protein…
- CACNB4 Voltage-dependent L-type calcium channel subunit beta-4 is a protein that in humans is encoded by the CACNB4 gene. This gene encodes a member of the beta…
- SCN3B Sodium channel subunit beta-3 is a protein that in humans is encoded by the SCN3B gene. Two alternatively spliced variants, encoding the same protein,…
- CACNB2 Voltage-dependent L-type calcium channel subunit beta-2 is a protein that in humans is encoded by the CACNB2 gene. Mutation in the CACNB2 gene are associated…
- Dravet syndrome Dravet syndrome (DS), previously known as severe myoclonic epilepsy of infancy (SMEI), is an autosomal dominant genetic disorder which causes a catastrophic…