Everything about CACNB2

🧭 Start here: a 6-step reading path

1. Read the overview: CACNB2A 5-minute orientation
2. Skim a recent paper: Epigenetic mechanism of L-type calcium channel β-subunit downregulation in short QT human induced pluripotent stem cell-derived cardiomyocytes with CACNB2 mutationInfluential work since 2022
3. Read the landmark paper: Genetic variations in CYP17A1, CACNB2 and PLEKHA7 are associated with blood pressure and/or hypertension in she ethnic minority of ChinaCited 59 times
4. Go sideways: CACNB4A closely related topic
5. Go sideways: CACNB3A closely related topic

🏆 Landmark papers (most cited)

• Genetic variations in CYP17A1, CACNB2 and PLEKHA7 are associated with blood pressure and/or hypertension in she ethnic minority of China

  Yinghua Lin, Xiaolan Lai, Bin Chen · 2011 · Atherosclerosis · 59 citations

• Moderate Calcium Channel Dysfunction in Adult Mice with Inducible Cardiomyocyte-specific Excision of the cacnb2 Gene

  Marcel Meissner, Petra Weissgerber, Juan E. Camacho Londoño · 2011 · Journal of Biological Chemistry · 57 citations

• Integrated Pathway-Based Approach Identifies Association between Genomic Regions at CTCF and CACNB2 and Schizophrenia

  Dilafruz Juraeva, Britta Haenisch, Marc Zapatka · 2014 · PLoS Genetics · 52 citations

• Rare Mutations of CACNB2 Found in Autism Spectrum Disease-Affected Families Alter Calcium Channel Function

  Alexandra F. S. Breitenkamp, Jan Matthes, Robert Daniel Nass · 2014 · PLoS ONE · 47 citations

• Regulation of cardiac CACNB2 by microRNA-499: Potential role in atrial fibrillation

  Tian-You Ling, Xiao-Li Wang, Qiang Chai · 2017 · BBA Clinical · 45 citations

• CACNB2: An Emerging Pharmacological Target for Hypertension, Heart Failure, Arrhythmia and Mental Disorders

  Nikolai Soldatov · 2015 · Current Molecular Pharmacology · 41 citations

• Voltage‐gated calcium channel CACNB2 (β2.1) protein is required in the heart for control of cell proliferation and heart tube integrity

  Yelena Chernyavskaya, Alicia M. Ebert, Emily Milligan · 2012 · Developmental Dynamics · 35 citations

• Bipolar‐associated miR‐499‐5p controls neuroplasticity by downregulating the Cav1.2 subunit CACNB2

  Helena C Martins, Carlotta Gilardi, A Özge Sungur · 2022 · The EMBO Reports · 23 citations

🆕 Influential since 2022

• Epigenetic mechanism of L-type calcium channel β-subunit downregulation in short QT human induced pluripotent stem cell-derived cardiomyocytes with CACNB2 mutation

  Rujia Zhong, Feng Zhang, Zhen Yang · 2022 · EP Europace · 15 citations

• A Preclinical Study on Brugada Syndrome with a CACNB2 Variant Using Human Cardiomyocytes from Induced Pluripotent Stem Cells

  Rujia Zhong, Theresa Schimanski, Feng Zhang · 2022 · International Journal of Molecular Sciences · 14 citations

• A Post-GWAS Functional Analysis Confirming Effects of Three BTA13 Genes CACNB2, SLC39A12, and ZEB1 on Dairy Cattle Reproduction

  Abdul Sammad, Hailiang Zhang, Rui Shi · 2022 · Frontiers in Genetics · 4 citations

• Sudden cardiac arrest in a patient with malignant mitral valve prolapse with CACNB2 gene mutation: a simple coincidence or coexistence?—a case report

  Nirmalatiban Parthiban, Huzairi Sani · 2023 · European Heart Journal - Case Reports · 3 citations

• Genetic evidence for amlodipine’s protective role in gastroesophageal reflux disease: A focus on CACNB2

  Liuzhao Zhang, Quanwang Chu, Shuyue Jiang · 2025 · PLOS ONE · 1 citations

📚 Books worth reading

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🔗 Related topics

• CACNB4 Voltage-dependent L-type calcium channel subunit beta-4 is a protein that in humans is encoded by the CACNB4 gene. This gene encodes a member of the beta…
• CACNB3 Voltage-dependent L-type calcium channel subunit beta-3 is a protein that in humans is encoded by the CACNB3 gene. Voltage-dependent calcium channel GRCh38:…
• KCNMB2 Calcium-activated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNMB2 gene. Big Potassium (BK) channels are large conductance…
• CACNB1 Voltage-dependent L-type calcium channel subunit beta-1 is a protein that in humans is encoded by the CACNB1 gene. The protein encoded by this gene belongs…
• CACNA1B The voltage-dependent N-type calcium channel subunit alpha-1B is a protein that in humans is encoded by the CACNA1B gene. The α1B protein, together with…
• CACNG1 Voltage-dependent calcium channel gamma-1 subunit is a protein that in humans is encoded by the CACNG1 gene. L-type calcium channels are composed of five…
• KCNMB4 Calcium-activated potassium channel subunit beta-4 is a protein that in humans is encoded by the KCNMB4 gene. MaxiK channels are large conductance, voltage…
• CACNG4 Voltage-dependent calcium channel gamma-4 subunit is a protein that in humans is encoded by the CACNG4 gene. L-type calcium channels are composed of five…