Live briefing
Everything about PTPRK
Protein-coding gene in the species Homo sapiens
Receptor-type tyrosine-protein phosphatase kappa is an enzyme that in humans is encoded by the PTPRK gene. PTPRK is also known as PTPkappa and PTPκ. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: PTPRKA 5-minute orientation
- Skim a recent paper: PTPRK regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesityInfluential work since 2022
- Read the landmark paper: Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell functionCited 251 times
- Go sideways: PTPRUA closely related topic
- Go sideways: PTPRTA closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function
Frequent PTPRK–RSPO3 fusions and RNF43 mutations in colorectal traditional serrated adenoma
Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus–encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells
Protein tyrosine phosphatase kappa (PTPRK) is a negative regulator of adhesion and invasion of breast cancer cells, and associates with poor prognosis of breast cancer
The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell–cell adhesion
PTPRK negatively regulates transcriptional activity of wild type and mutated oncogenic β-catenin and affects membrane distribution of β-catenin/E-cadherin complexes in cancer cells
The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer
THEMIS and PTPRK in celiac intestinal mucosa: coexpression in disease and after in vitro gliadin challenge
🆕 Influential since 2022
PTPRK regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity
Protein tyrosine phosphatase receptor type kappa (PTPRK) revisited: evolving insights into structure, function, and pathology
The receptor protein tyrosine phosphatase PTPRK promotes intestinal repair and catalysis-independent tumour suppression
PTPRK, an EGFR Phosphatase, Is Decreased in CeD Biopsies and Intestinal Organoids
Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains
📚 Books worth reading
Open Library didn't respond; try again in a moment.
🔗 Related topics
- PTPRU Receptor-type tyrosine-protein phosphatase PCP-2 (also known as PTP-pi, PTP lambda, hPTP-J, PTPRO and PTP psi), is an enzyme that in humans is encoded…
- PTPRT Receptor-type tyrosine-protein phosphatase T is an enzyme that in humans is encoded by the PTPRT gene. PTPRT is also known as PTPrho, PTPρ and human accelerated…
- PTPRG Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the PTPRG gene. The protein encoded by this gene is a member…
- PTPRM Receptor-type tyrosine-protein phosphatase mu is an enzyme that in humans is encoded by the PTPRM gene. The protein encoded by this gene is a member of…
- PTPRF Receptor-type tyrosine-protein phosphatase F is an enzyme that, in humans, is encoded by the PTPRF gene. The protein encoded by this gene is a member of…
- PTPRD Receptor-type tyrosine-protein phosphatase delta is an enzyme that, in humans, is encoded by the PTPRD gene. The protein encoded by this gene is a member…
- PTPN14 Tyrosine-protein phosphatase non-receptor type 14 is an enzyme that in humans is encoded by the PTPN14 gene. It is composes of a PTP (protein tyrosine…
- Mir-26 microRNA precursor family The miR-26 microRNA is a small non-coding RNA that is involved in regulating gene expression. The miR-26 family is composed of miR-26a-1, miR-26a-2 and…