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Everything about PRPF8
Protein-coding gene in the species Homo sapiens
Pre-mRNA-processing-splicing factor 8 is a protein that in humans is encoded by the PRPF8 gene. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: PRPF8A 5-minute orientation
- Skim a recent paper: PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicingInfluential work since 2022
- Read the landmark paper: PRPF8 defects cause missplicing in myeloid malignanciesCited 112 times
- Go sideways: Prp8A closely related topic
- Go sideways: PRPF31A closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
PRPF8 defects cause missplicing in myeloid malignancies
Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones
Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5′ splice site strength
Mutations in the Pre-mRNA Splicing-Factor Genes PRPF3 , PRPF8 , and PRPF31 in Spanish Families with Autosomal Dominant Retinitis Pigmentosa
circRNA-UBAP2 promotes the proliferation and inhibits apoptosis of ovarian cancer though miR-382-5p/PRPF8 axis
In vivo mutation of pre‐mRNA processing factor 8 (Prpf8) affects transcript splicing, cell survival and myeloid differentiation
Autosomal dominant retinitis pigmentosa-associated gene PRPF8 is essential for hypoxia-induced mitophagy through regulating ULK1 mRNA splicing
Autosomal Dominant Retinitis Pigmentosa with Intrafamilial Variability and Incomplete Penetrance in Two Families Carrying Mutations in PRPF8
🆕 Influential since 2022
PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing
PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects
Altered splicing machinery in lung carcinoids unveils NOVA1, PRPF8 and SRSF10 as novel candidates to understand tumor biology and expand biomarker discovery
Heterozygous variants in PRPF8 are associated with neurodevelopmental disorders
Retinitis pigmentosa–associated mutations in mouse Prpf8 cause misexpression of circRNAs and degeneration of cerebellar granule cells
📚 Books worth reading
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🔗 Related topics
- Prp8 Prp8 refers to both the Prp8 protein and Prp8 gene. Prp8's name originates from its involvement in pre-mRNA processing. The Prp8 protein is a large, highly…
- PRPF31 PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae), also known as PRPF31, is a protein which in humans is encoded by the PRPF31 gene. PRPF31 is…
- SNRNP40 U5 small nuclear ribonucleoprotein 40 kDa protein (or U5-40K) is a protein that in humans is encoded by the gene SNRNP40 (previously WDR57). This gene…
- PRPF3 U4/U6 small nuclear ribonucleoprotein Prp3 is a protein that in humans is encoded by the PRPF3 gene. The removal of introns from nuclear pre-mRNAs occurs…
- SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase is an enzyme that in humans is encoded by the SNRNP200 gene. This enzyme functions to unwind the U4/U6…
- DDX23 Probable ATP-dependent RNA helicase DDX23 is an enzyme that in humans is encoded by the DDX23 gene. This gene encodes a member of the DEAD box protein…
- EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component is a protein that in humans is encoded by the EFTUD2 gene. Heterozygous loss-of-function mutations…
- Spliceosome A spliceosome is a large complex of proteins and RNA (ribonucleoprotein) that functions to remove introns from pre-mRNA, a process called RNA splicing…