Everything about Endoreduplication
Replication of the nuclear genome without mitosis
Endoreduplication is replication of the nuclear genome in the absence of mitosis, which leads to elevated nuclear gene content and polyploidy. Endoreduplication can be understood simply as a variant form of the mitotic cell cycle (G1-S-G2-M) in which mitosis is circumvented entirely, due to modulation of cyclin-dependent kinase (CDK) activity. Examples of endoreduplication characterised in arthropod, mammalian, and plant species suggest that it is a universal developmental mechanism responsible for the differentiation and morphogenesis of cell types that fulfill an array of biological functions. While endoreduplication is often limited to specific cell types in animals, it is considerably more widespread in plants, such that polyploidy can be detected in the majority of plant tissues. Polyploidy and aneuploidy are common phenomena in cancer cells. Given that oncogenesis and endoreduplication likely involve subversion of common cell cycle regulatory mechanisms, a thorough understanding of endoreduplication may provide important insights for cancer biology. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: EndoreduplicationA 5-minute orientation
- Skim a recent paper: ERF4 interacts with and antagonizes TCP15 in regulating endoreduplication and cell growth in ArabidopsisInfluential work since 2022
- Pick up a classic book: Eukaryotic Cell CycleThe most-reprinted book on the subject
- Read the landmark paper: Effects of p21 Cip1/Waf1 at Both the G 1 /S and the G 2 /M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing EndoreduplicationCited 624 times
- Go sideways: Cell cycleA closely related topic
- Go sideways: Cyclin AA closely related topic
📖 Definitions
Noun The replication of chromosomes without mitotic cell division.
🏆 Landmark papers (most cited)
Effects of p21 Cip1/Waf1 at Both the G 1 /S and the G 2 /M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication
“Big it up”: endoreduplication and cell-size control in plants
Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa–DPa transcription factor
The mitotic inhibitor ccs52 is required for endoreduplication and ploidy‐dependent cell enlargement in plants
Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis
Cell Expansion and Endoreduplication Show a Large Genetic Variability in Pericarp and Contribute Strongly to Tomato Fruit Growth
The Cyclin-Dependent Kinase Inhibitor KRP2 Controls the Onset of the Endoreduplication Cycle during Arabidopsis Leaf Development through Inhibition of Mitotic CDKA;1 Kinase Complexes
Investigating the hows and whys of DNA endoreduplication
🆕 Influential since 2022
ERF4 interacts with and antagonizes TCP15 in regulating endoreduplication and cell growth in Arabidopsis
The UBP14-CDKB1;1-CDKG2 cascade controls endoreduplication and cell growth in Arabidopsis
CRISPR/Cas9 edited SlGT30 improved both drought resistance and fruit yield through endoreduplication
Endoreduplication in plant organogenesis: a means to boost fruit growth
Rhizobial infection of 4C cells triggers their endoreduplication during symbiotic nodule development in soybean
📚 Books worth reading
Eukaryotic Cell CycleBryant/Franis · 2008- 📕The genetic analysis of endoreduplication in Drosophila melanogasterBruce Hunter Reed · 1992
- 📕New plant physiology researchRobert T. Devane · 2009
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Cell cycle The cell cycle, or cell-division cycle, is the sequence of events that take place in a cell and lead to its division into two daughter cells. These events…
- Cyclin A Cyclin A is a member of the cyclin family, a group of proteins that function in regulating progression through the cell cycle. The stages that a cell passes…
- DNA re-replication DNA re-replication (or simply rereplication) is an undesirable and possibly fatal occurrence in eukaryotic cells in which the genome is replicated more…
- G1/S transition The G1/S transition is a stage in the cell cycle at the boundary between the G1 phase, in which the cell grows, and the S phase, during which DNA is replicated…
- Cell cycle checkpoint Cell cycle checkpoints are control mechanisms in the eukaryotic cell cycle which ensure its proper progression. Each checkpoint serves as a potential terminatio…
- E2F E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six…
- Anaphase-promoting complex Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the…
- S phase S phase (Synthesis phase) is the phase of the cell cycle in which DNA is replicated, occurring between G1 phase and G2 phase. Since accurate duplication…