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Everything about DNA re-replication

Undesirable occurrence in eukaryotic cells

DNA re-replication is an undesirable and possibly fatal occurrence in eukaryotic cells in which the genome is replicated more than once per cell cycle. Rereplication is believed to lead to genomic instability and has been implicated in the pathologies of a variety of human cancers. To prevent rereplication, eukaryotic cells have evolved multiple, overlapping mechanisms to inhibit chromosomal DNA from being partially or fully rereplicated in a given cell cycle. These control mechanisms rely on cyclin-dependent kinase (CDK) activity. DNA replication control mechanisms cooperate to prevent the relicensing of replication origins and to activate cell cycle and DNA damage checkpoints. DNA rereplication must be strictly regulated to ensure that genomic information is faithfully transmitted through successive generations. Wikipedia →

🧭 Start here: a 6-step reading path

  1. Read the overview: DNA re-replicationA 5-minute orientation
  2. Skim a recent paper: Hallmarks of DNA replication stressInfluential work since 2022
  3. Pick up a classic book: Drug targets in kinetoplastid parasitesThe most-reprinted book on the subject
  4. Read the landmark paper: Preventing re-replication of chromosomal DNACited 557 times
  5. Go sideways: Control of chromosome duplicationA closely related topic
  6. Go sideways: Pre-replication complexA closely related topic

📖 Definitions

No dictionary entry for this exact phrase.

🗂️ The subject at a glance

  1. Initiating replication at origins
  2. Origin licensing
  3. Two-state model for DNA replication regulation
  4. Replication regulation
  5. Consequences of rereplication in eukaryotic cells
  6. Preventing rereplication
  7. Rereplication in cancer
  8. Endoreduplication

🏆 Landmark papers (most cited)

🆕 Influential since 2022

📚 Books worth reading

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics