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Everything about Pre-replication complex
Protein complex formed during initiation of DNA replication
A pre-replication complex (pre-RC) is a protein complex that forms at the origin of replication during the initiation step of DNA replication. Formation of the pre-RC is required for DNA replication to occur. Complete and faithful replication of the genome ensures that each daughter cell will carry the same genetic information as the parent cell. Accordingly, formation of the pre-RC is a very important part of the cell cycle. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: Pre-replication complexA 5-minute orientation
- Skim a recent paper: Selective interactions at pre-replication complexes categorize baseline and dormant originsInfluential work since 2022
- Pick up a classic book: Statistics for sensory and consumer scienceThe most-reprinted book on the subject
- Read the landmark paper: Mutations in the pre-replication complex cause Meier-Gorlin syndromeCited 242 times
- Go sideways: Origin recognition complexA closely related topic
- Go sideways: Control of chromosome duplicationA closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🏆 Landmark papers (most cited)
Mutations in the pre-replication complex cause Meier-Gorlin syndrome
Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex
Eukaryotic DNA replication: from pre-replication complex to initiation complex
Stability, chromatin association and functional activity of mammalian pre‐replication complex proteins during the cell cycle
The human pre-replication complex is an open complex
Phosphorylation of Mcm2 by Cdc7 Promotes Pre-replication Complex Assembly during Cell-Cycle Re-entry
Structural mechanism of RPA loading on DNA during activation of a simple pre‐replication complex
Dynamics of pre-replication complex proteins during the cell division cycle
🆕 Influential since 2022
Selective interactions at pre-replication complexes categorize baseline and dormant origins
Precise and Rapid Replication of Complex‐Shaped Fused Silica Optics
The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stress
A DNA replication-independent function of pre-replication complex genes during cell invasion in C. elegans
Hsp90 Inhibitors Prevent HSV-1 Replication by Directly Targeting UL42-Hsp90 Complex
📚 Books worth reading
Statistics for sensory and consumer scienceTormod Næs · 2010- 📕Cytological assessment of urine by immunostaining for proteins of the pre-replication complexJohn Peter Brown · 2003
Protein conformation · 2008
Introduction to making very big booksUnited States. Congress. Senate. Committee on Pensions · 2011
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Origin recognition complex In molecular biology, origin recognition complex (ORC) is a multi-subunit DNA binding complex (6 subunits) that binds in all eukaryotes and archaea in…
- Control of chromosome duplication In cell biology, eukaryotes possess a regulatory system that ensures that DNA replication occurs only once per cell cycle. A key feature of the DNA replication…
- Minichromosome maintenance The minichromosome maintenance protein complex (MCM) is a DNA helicase essential for genomic DNA replication. Eukaryotic MCM consists of six gene products…
- DNA re-replication DNA re-replication (or simply rereplication) is an undesirable and possibly fatal occurrence in eukaryotic cells in which the genome is replicated more…
- Eukaryotic DNA replication Eukaryotic DNA replication is a conserved mechanism that restricts DNA replication to once per cell cycle. Eukaryotic DNA replication of chromosomal DNA…
- Origin of replication The origin of replication (also called the replication origin) is a particular sequence in a genome at which replication is initiated. Propagation of the…
- Cdc6 Cdc6, or cell division cycle 6, is a protein in eukaryotic cells. It is mainly studied in the budding yeast Saccharomyces cerevisiae (P09119). It is an…
- DNA replication factor CDT1 CDT1 (Chromatin licensing and DNA replication factor 1) is a protein that in humans is encoded by the CDT1 gene. It is a licensing factor that functions…