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Everything about E2F

Family of transcription factors

E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as repressors: E2F3b, E2F4-8. All of them are involved in the cell cycle regulation and synthesis of DNA in mammalian cells. E2Fs as TFs bind to the TTTCCCGC consensus binding site in the target promoter sequence. With the exception of E2F6, E2F7 and E2F8, most members possess a pocket protein–binding domain, whose best known binding partner is the retinoblastoma protein (pRb), and a transactivation domain. Wikipedia →

🧭 Start here: a 6-step reading path

  1. Read the overview: E2FA 5-minute orientation
  2. Skim a recent paper: RB1-deficient prostate tumor growth and metastasis are vulnerable to ferroptosis induction via the E2F/ACSL4 axisInfluential work since 2022
  3. Pick up a classic book: A Farewell to ArmsThe most-reprinted book on the subject
  4. Read the landmark paper: Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular SenescenceCited 2,103 times
  5. Go sideways: E2F4A closely related topic
  6. Go sideways: Retinoblastoma proteinA closely related topic

📖 Definitions

Noun E2F binding factor, acronym from early region 2 binding factor. A transcription factor in eukaryotic DNA synthesis

🗂️ The subject at a glance

  1. E2F family
  2. Genes
  3. Structure
  4. Role in the cell cycle
  5. E2F/pRb complexes
  6. Transcriptional targets

🏆 Landmark papers (most cited)

🆕 Influential since 2022

📚 Books worth reading

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics