Everything about Conserved non-coding sequence

🧭 Start here: a 6-step reading path

1. Read the overview: Conserved non-coding sequenceA 5-minute orientation
2. Skim a recent paper: PlantPAN 4.0: updated database for identifying conserved non-coding sequences and exploring dynamic transcriptional regulation in plant promotersInfluential work since 2022
3. Pick up a classic book: Principles of gene manipulation and genomicsThe most-reprinted book on the subject
4. Read the landmark paper: In vivo enhancer analysis of human conserved non-coding sequencesCited 1,067 times
5. Go sideways: Gene desertA closely related topic
6. Go sideways: Non-coding DNAA closely related topic

🏆 Landmark papers (most cited)

• In vivo enhancer analysis of human conserved non-coding sequences

  Len A. Pennacchio, Nadav Ahituv, Alan M. Moses · 2006 · Nature · 1,067 citations

• Highly Conserved Non-Coding Sequences Are Associated with Vertebrate Development

  Adam Woolfe, Martin Goodson, Debbie K Goode · 2004 · PLoS Biology · 771 citations

• Highly conserved non-coding elements on either side of SOX9 associated with Pierre Robin sequence

  Sabina Benko, Judy A Fantes, Jeanne Amiel · 2009 · Nature Genetics · 418 citations

• Plant conserved non-coding sequences and paralogue evolution

  Steven Lockton, Brandon S. Gaut · 2005 · Trends in Genetics · 138 citations

• Enrichment of regulatory signals in conserved non-coding genomic sequence

  Samuel Levy, Sridhar Hannenhalli, Christopher Workman · 2001 · Bioinformatics · 92 citations

• Positionally-conserved but sequence-diverged: identification of long non-coding RNAs in the Brassicaceae and Cleomaceae

  Setareh Mohammadin, Patrick P. Edger, J. Chris Pires · 2015 · BMC Plant Biology · 67 citations

• Making (anti)sense of non-coding sequence conservation

  D. J. Lipman · 1997 · Nucleic Acids Research · 64 citations

• Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences

  Patrick Gilligan, Sydney Brenner, Byrappa Venkatesh · 2002 · Gene · 49 citations

🆕 Influential since 2022

• PlantPAN 4.0: updated database for identifying conserved non-coding sequences and exploring dynamic transcriptional regulation in plant promoters

  Chi-Nga Chow, Chien-Wen Yang, Nai-Yun Wu · 2023 · Nucleic Acids Research · 170 citations

• A Conserved Long Intergenic Non-coding RNA Containing snoRNA Sequences, lncCOBRA1, Affects Arabidopsis Germination and Development

  Marianne C. Kramer, Hee Jong Kim, Kyle R. Palos · 2022 · Frontiers in Plant Science · 18 citations

• Conserved structured domains in plant non-coding RNA enod40, their evolution and recruitment of sequences from transposable elements

  Alexander P Gultyaev, Celine Koster, Diederik Cames van Batenburg · 2023 · NAR Genomics and Bioinformatics · 12 citations

• Identification of clade-wide putative cis-regulatory elements from conserved non-coding sequences in Cucurbitaceae genomes

  Hongtao Song, Qi Wang, Zhonghua Zhang · 2023 · Horticulture Research · 10 citations

• Deletion upstream of MAB21L2 highlights the importance of evolutionarily conserved non-coding sequences for eye development

  Fabiola Ceroni, Munevver B. Cicekdal, Richard Holt · 2024 · Nature Communications · 9 citations

📚 Books worth reading

• Principles of gene manipulation and genomicsS. B. Primrose · 2006
• BIOINFORMATICS ALGORITHMS,VOL.IIPhillip Compeau, Pavel Pevzner · 2015
• 📕Pipelines 2015Md.) Pipelines (Conference) (2015 Baltimore · 2015
• 📕ICTE 2015China) International Conference On Transportation Engineering (5th 2015 Dalian Shi · 2015
• 📕Tech15projects.com · 2014
• A Heritage of Open Air Square Temple Discovered In Russia · 2010
• A TOUR OF THE WORLDMalik Mansab Khan, Muhammad Rafique Abdul Aziz · 2025

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics

• Gene desert Gene deserts are large intergenic regions of mammalians genomes (> 640 kb) that are devoid of genes. They contain many known functional elements, including…
• Non-coding DNA Non-coding DNA (ncDNA) sequences are components of an organism's DNA that do not encode protein sequences. Some non-coding DNA is transcribed into functional…
• Intergenic region An intergenic region is a stretch of DNA sequences located between genes. Intergenic regions may contain functional elements and junk DNA. Intergenic regions…
• Long non-coding RNA Long non-coding RNAs (long ncRNAs, lncRNA) are a type of RNA, generally defined as transcripts of more than 200 nucleotides that are not translated into…
• Hox gene Hox genes, a subset of homeobox genes, are a group of related genes that specify regions of the body plan of an embryo along the head-tail axis of animals…
• Genome evolution Genome evolution is the process by which a genome changes in structure (sequence) or size over time. The study of genome evolution involves multiple fields…
• Junk DNA Junk DNA (non-functional DNA) is a DNA sequence that has no known biological function. Most organisms have some junk DNA in their genomes—mostly pseudogenes…
• HOTAIR HOTAIR (for HOX transcript antisense RNA) is a human gene located between HOXC11 and HOXC12 on chromosome 12. It is the first example of an RNA expressed…