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Everything about Biochip
Substrates performing biochemical reactions
In molecular biology, biochips are engineered substrates that can host large numbers of simultaneous biochemical reactions. One of the goals of biochip technology is to efficiently screen large numbers of biological analytes, with potential applications ranging from disease diagnosis to detection of bioterrorism agents. For example, digital microfluidic biochips are under investigation for applications in biomedical fields. In a digital microfluidic biochip, a group of (adjacent) cells in the microfluidic array can be configured to work as storage, functional operations, as well as for transporting fluid droplets dynamically. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: BiochipA 5-minute orientation
- Skim a recent paper: Surface Modification Strategies for Biomedical Applications: Enhancing Cell–Biomaterial Interfaces and Biochip PerformancesInfluential work since 2022
- Pick up a classic book: Integrated microfabricated biodevicesThe most-reprinted book on the subject
- Read the landmark paper: Self-Contained, Fully Integrated Biochip for Sample Preparation, Polymerase Chain Reaction Amplification, and DNA Microarray DetectionCited 557 times
- Go sideways: MicroarrayA closely related topic
- Go sideways: MAGIChipA closely related topic
📖 Definitions
Noun A microchip made from biological macromolecules (especially DNA) rather than a semiconductor.
Noun An identification chip fitted into the flesh of an animal.
Verb To fit (an animal) with such a chip.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Self-Contained, Fully Integrated Biochip for Sample Preparation, Polymerase Chain Reaction Amplification, and DNA Microarray Detection
A PDMS/paper/glass hybrid microfluidic biochip integrated with aptamer-functionalized graphene oxide nano-biosensors for one-step multiplexed pathogen detection
Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip
An ultra-high-throughput spiral microfluidic biochip for the enrichment of circulating tumor cells
Versatile label free biochip for the detection of circulating tumor cells from peripheral blood in cancer patients
Microfluidic Immuno-Biochip for Detection of Breast Cancer Biomarkers Using Hierarchical Composite of Porous Graphene and Titanium Dioxide Nanofibers
Proteinchip® surface enhanced laser desorption/ionization (SELDI) mass spectrometry: a novel protein biochip technology for detection of prostate cancer biomarkers in complex protein mixtures
Molecularly engineered p(HEMA)-based hydrogels for implant biochip biocompatibility
🆕 Influential since 2022
Surface Modification Strategies for Biomedical Applications: Enhancing Cell–Biomaterial Interfaces and Biochip Performances
Smartphone assisted portable biochip for non-invasive simultaneous monitoring of glucose and insulin towards precise diagnosis of prediabetes/diabetes
An immunogold single extracellular vesicular RNA and protein ( Au SERP) biochip to predict responses to immunotherapy in non‐small cell lung cancer patients
Lys-AuNPs@MoS 2 Nanocomposite Self-Assembled Microfluidic Immunoassay Biochip for Ultrasensitive Detection of Multiplex Biomarkers for Cardiovascular Diseases
Simultaneous detection of SARS-CoV-2 S1 protein by using flexible electrochemical and Raman enhancing biochip
📚 Books worth reading
Integrated microfabricated biodevicesAndras Guttman · 2001
Cell-based microarraysElla Palmer · 2011- 📕Optimization of Trustworthy Biomolecular Quantitative Analysis Using Cyber-Physical Microfluidic PlatformsMohamed Ibrahim, Krishnendu Chakrabarty · 2020
Biochip TechnologyJing Cheng · 2001
Biochips as Pathways to Drug DiscoveryGary Hardiman · 2006
CMOS biotechnologyDonhee Ham · 2007
Microchip-Based Assay SystemsPierre N. Floriano · 2007
Theoretical microfluidicsHenrik Bruus · 2007
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Microarray Microarray at Wikipedia's sister projects Definitions from Wiktionary Textbooks from Wikibooks Resources from Wikiversity A microarray is a multiplex lab-on-a-c…
- MAGIChip MAGIChips, also known as "microarrays of gel-immobilized compounds on a chip" or "three-dimensional DNA microarrays", are devices for molecular hybridization…
- Bio-MEMS Bio-MEMS is an abbreviation for biomedical (or biological) microelectromechanical systems. Bio-MEMS have considerable overlap, and is sometimes considered…
- Protein microarray A protein microarray (or protein chip) is a high-throughput method used to track the interactions and activities of proteins, and to determine their function…
- DNA microarray A DNA microarray (also commonly known as a DNA chip or biochip) is a collection of microscopic DNA spots attached to a solid surface. Scientists use DNA…
- ChIP-on-chip ChIP-on-chip (also known as ChIP-chip) is a technology that combines chromatin immunoprecipitation ('ChIP') with DNA microarray ("chip"). Like regular…
- Antibody microarray An antibody microarray (also known as antibody array) is a specific form of protein microarray. In this technology, a collection of captured antibodies…
- Centrifugal micro-fluidic biochip The centrifugal micro-fluidic biochip or centrifugal micro-fluidic biodisk is a type of lab-on-a-chip technology, also known as lab-on-a-disc, that can…