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Everything about XIST
Non-coding RNA
Xist is a non-coding RNA transcribed from the X chromosome of the placental mammals that acts as a major effector of the X-inactivation process. It is a component of the Xic – X-chromosome inactivation centre – along with two other RNA genes and two protein genes. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: XISTA 5-minute orientation
- Skim a recent paper: Xist ribonucleoproteins promote female sex-biased autoimmunityInfluential work since 2022
- Pick up a classic book: AfricaThe most-reprinted book on the subject
- Read the landmark paper: m6A RNA methylation promotes XIST-mediated transcriptional repressionCited 1,703 times
- Go sideways: TsixA closely related topic
- Go sideways: X-inactivationA closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🏆 Landmark papers (most cited)
m6A RNA methylation promotes XIST-mediated transcriptional repression
Requirement for Xist in X chromosome inactivation
The human XIST gene: Analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus
The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3
Systematic Discovery of Xist RNA Binding Proteins
The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome
The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus
XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure.
🆕 Influential since 2022
Xist ribonucleoproteins promote female sex-biased autoimmunity
Targeting Xist with compounds that disrupt RNA structure and X inactivation
Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome
Long noncoding RNA XIST: Mechanisms for X chromosome inactivation, roles in sex-biased diseases, and therapeutic opportunities
XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells
📚 Books worth reading
AfricaXist Publishing · 2012- 📕UXist Publishing · 2019
- 📕I See EightXist Publishing · 2019
- 📕BlackXist Publishing · 2019
- 📕PurpleXist Publishing · 2019
- 📕CXist Publishing · 2019
- 📕Mole Goes to the BeachXist Publishing · 2019
- 📕Mole Plays PirateXist Publishing · 2019
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Tsix Tsix is a non-coding RNA gene that is antisense to the Xist RNA. Tsix binds Xist during X chromosome inactivation. The name Tsix comes from the reverse…
- X-inactivation X-inactivation (also called Lyonization, after English geneticist Mary Lyon) is a process by which one of the copies of the X chromosome is inactivated…
- Barr body A Barr body (named after discoverer Murray Barr) or X-chromatin is an inactive X chromosome. In species with XY sex-determination (including humans), females…
- Long non-coding RNA Long non-coding RNAs (long ncRNAs, lncRNA) are a type of RNA, generally defined as transcripts of more than 200 nucleotides that are not translated into…
- Sex-chromosome dosage compensation Dosage compensation is the process by which organisms equalize the expression of genes between members of different biological sexes. Across species, different…
- X-chromosome reactivation X chromosome reactivation (XCR) is the process by which the inactive X chromosome (the Xi) is re-activated in the cells of eutherian female mammals. Therian…
- Polycomb-group proteins Polycomb-group proteins (PcG proteins) are a family of protein complexes first discovered in fruit flies that can remodel chromatin such that epigenetic…
- Epigenetics of human development Epigenetics play an important role in animal development, including the development of human beings. Various epigenetic markers serve different roles that…