Everything about Stop codon
Codon that marks the end of a protein-coding sequence
In molecular biology, a stop codon is a codon that signals the termination of the translation process of the current protein. Most codons in messenger RNA correspond to the addition of an amino acid to a growing polypeptide chain, which may ultimately become a protein; stop codons signal the termination of this process by binding release factors, which cause the ribosomal subunits to disassociate, releasing the amino acid chain. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: Stop codonA 5-minute orientation
- Skim a recent paper: Widespread stop-codon recoding in bacteriophages may regulate translation of lytic genesInfluential work since 2022
- Pick up a classic book: Annual review of genomics and human geneticsThe most-reprinted book on the subject
- Read the landmark paper: Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop CodonsCited 4,073 times
- Go sideways: Nonsense mutationA closely related topic
- Go sideways: Nonsense suppressorA closely related topic
📖 Definitions
Noun a sequence of three RNA nucleotides (A, C, G or U) that instruct the synthesis, or translation, of a protein to stop. The three-letter stop codon sequences have been given names: "UAG" is amber, "UGA" is opal, and "UAA" is ochre.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation
MACSE v2: Toolkit for the Alignment of Coding Sequences Accounting for Frameshifts and Stop Codons
MACSE: Multiple Alignment of Coding SEquences Accounting for Frameshifts and Stop Codons
🆕 Influential since 2022
Widespread stop-codon recoding in bacteriophages may regulate translation of lytic genes
Short tRNA anticodon stem and mutant eRF1 allow stop codon reassignment
Aqp4 stop codon readthrough facilitates amyloid-β clearance from the brain
Extended stop codon context predicts nonsense codon readthrough efficiency in human cells
Engineering a genomically recoded organism with one stop codon
📚 Books worth reading
Annual review of genomics and human geneticsAravinda Chakravarti, Eric D. Green · 2014- 📕Dynamics of Stop-codon Recognition by Release Factor 1Colin Donald Kinz-Thompson · 2016
- 📕Cytopathic avian retroviruses and the death receptor TVBSara Rene Klucking · 2003
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Nonsense mutation In genetics, a nonsense mutation is a point mutation in a sequence of DNA that results in a nonsense codon, or a premature stop codon in the transcribed…
- Nonsense suppressor A nonsense suppressor is a factor which can inhibit the effect of the nonsense mutation. Nonsense suppressors can be generally divided into two classes:…
- Genetic code Genetic code is a set of rules used by living cells to translate information encoded within genetic material (DNA or RNA sequences of nucleotide triplets…
- DNA and RNA codon tables A codon table can be used to translate a genetic code into a sequence of amino acids. The standard genetic code is traditionally represented as an RNA…
- Suppressor mutation A suppressor mutation is a second mutation that alleviates or reverts the phenotypic effects of an already existing mutation in a process defined synthetic…
- Translation (biology) Translation is the process in biological cells in which proteins are produced using RNA molecules as templates. The generated protein is a sequence of…
- Expanded genetic code An expanded genetic code is an artificially modified genetic code in which one or more specific codons have been re-allocated to encode an amino acid that…
- Silent mutation Silent mutations, also called synonymous or samesense mutations, are mutations in DNA that do not have an observable effect on the organism's phenotype…