Everything about Expanded genetic code

🧭 Start here: a 6-step reading path

1. Read the overview: Expanded genetic codeA 5-minute orientation
2. Skim a recent paper: Recombinant and genetic code expanded collagen-like protein as a tailorable biomaterialInfluential work since 2022
3. Pick up a classic book: The Conspirators HierarchyThe most-reprinted book on the subject
4. Read the landmark paper: An Expanded Eukaryotic Genetic CodeCited 758 times
5. Go sideways: XenobiologyA closely related topic
6. Go sideways: Genetic codeA closely related topic

🏆 Landmark papers (most cited)

• An Expanded Eukaryotic Genetic Code

  Jason W. Chin, T. Ashton Cropp, J. Christopher Anderson · 2003 · Science · 758 citations

• A chemical toolkit for proteins — an expanded genetic code

  Jianming Xie, Peter G. Schultz · 2006 · Nature Reviews Molecular Cell Biology · 388 citations

• An expanded genetic code with a functional quadruplet codon

  J. Christopher Anderson, Ning Wu, Stephen W. Santoro · 2004 · Proceedings of the National Academy of Sciences · 305 citations

• Probing Protein Structure and Function with an Expanded Genetic Code

  Virginia W. Cornish, David Mendel, Peter G. Schultz · 1995 · Angewandte Chemie International Edition in English · 220 citations

• Optimized clinical performance of growth hormone with an expanded genetic code

  Ho Cho, Tom Daniel, Ying Ji Buechler · 2011 · Proceedings of the National Academy of Sciences · 191 citations

• Progress toward the evolution of an organism with an expanded genetic code

  David R. Liu, Peter G. Schultz · 1999 · Proceedings of the National Academy of Sciences · 171 citations

• Site-Directed Mutagenesis with an Expanded Genetic Code

  D Mendel, V W Cornish, P G Schultz · 1995 · Annual Review of Biophysics and Biomolecular Structure · 155 citations

• Protein evolution with an expanded genetic code

  Chang C. Liu, Antha V. Mack, Meng-Lin Tsao · 2008 · Proceedings of the National Academy of Sciences · 142 citations

🆕 Influential since 2022

• Recombinant and genetic code expanded collagen-like protein as a tailorable biomaterial

  Ilamaran Meganathan, Mohandass Pachaiyappan, Mayilvahanan Aarthy · 2022 · Materials Horizons · 48 citations

• Ancestral archaea expanded the genetic code with pyrrolysine

  Li-Tao Guo, Kazuaki Amikura, Han-Kai Jiang · 2022 · Journal of Biological Chemistry · 29 citations

• Expanding the genetic code

  Peter Schultz · 2022 · Protein Science · 22 citations

• Discovery, implications and initial use of semi-synthetic organisms with an expanded genetic alphabet/code

  Floyd E. Romesberg · 2023 · Philosophical Transactions of the Royal Society B · 21 citations

• Recent advances in the expanding genetic code

  Michael L. Pigula, Peter G. Schultz · 2024 · Current Opinion in Chemical Biology · 16 citations

📚 Books worth reading

• The Conspirators HierarchyJohn Coleman · 1992
• Treaty Occupationay ToxicologySuelen Queiroz · 2010
• Engineering the Genetic CodeNediljko Budisa · 2006
• The genetic code and the origin of life · 2004
• The human genomeJulia E. Richards · 2011
• The Human Planet · 2009
• A TOUR OF THE WORLDMalik Mansab Khan, Muhammad Rafique Abdul Aziz · 2025
• survival companion for medical students, graduates and interns · 2014

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics

• Xenobiology Xenobiology (XB) is a subfield of synthetic biology, the study of synthesizing and manipulating biological devices and systems. The name xenobiology derives…
• Genetic code Genetic code is a set of rules used by living cells to translate information encoded within genetic material (DNA or RNA sequences of nucleotide triplets…
• Nediljko Budisa Nediljko "Ned" Budisa (Croatian: Nediljko Budiša; born 21 November 1966) is a Croatian biochemist, professor and holder of the Tier 1 Canada Research Chair…
• Translation (biology) Translation is the process in biological cells in which proteins are produced using RNA molecules as templates. The generated protein is a sequence of…
• Aminoacyl tRNA synthetase An aminoacyl-tRNA synthetase (aaRS or ARS), also called aminoacyl-tRNA ligase, is an enzyme that attaches the appropriate amino acid onto its corresponding…
• Pyrrolysine Pyrrolysine (symbol Pyl or O), encoded by the "amber" stop codon UAG, is a proteinogenic amino acid that is used in some methanogenic archaea and in bacteria…
• Alloprotein An alloprotein is a novel synthetic protein containing one or more "non-natural" amino acids. Non-natural in the context means an amino acid either not…
• Wobble base pair A wobble base pair is a pairing between two nucleotides in RNA molecules that does not follow Watson–Crick base pair rules. The four main wobble base pairs…