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Everything about STARR-seq
Genetics method
STARR-seq is a method to assay enhancer activity for millions of candidates from arbitrary sources of DNA. It is used to identify the sequences that act as transcriptional enhancers in a direct, quantitative, and genome-wide manner. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: STARR-seqA 5-minute orientation
- Skim a recent paper: ATAC-STARR-seq reveals transcription factor–bound activators and silencers within chromatin-accessible regions of the human genomeInfluential work since 2022
- Read the landmark paper: Genome-Wide Quantitative Enhancer Activity Maps Identified by STARR-seqCited 1,187 times
- Go sideways: Enhancer (genetics)A closely related topic
- Go sideways: DNase I hypersensitive siteA closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Genome-Wide Quantitative Enhancer Activity Maps Identified by STARR-seq
STARR-seq — Principles and applications
Identification of Plant Enhancers and Their Constituent Elements by STARR-seq in Tobacco Leaves
STARR-seq identifies active, chromatin-masked, and dormant enhancers in pluripotent mouse embryonic stem cells
STARR‐seq and UMI‐STARR‐seq: Assessing Enhancer Activities for Genome‐Wide‐, High‐, and Low‐Complexity Candidate Libraries
Global Quantitative Mapping of Enhancers in Rice by STARR-Seq
STARRPeaker: uniform processing and accurate identification of STARR-seq active regions
Synthetic STARR-seq reveals how DNA shape and sequence modulate transcriptional output and noise
🆕 Influential since 2022
ATAC-STARR-seq reveals transcription factor–bound activators and silencers within chromatin-accessible regions of the human genome
An unbiased AAV-STARR-seq screen revealing the enhancer activity map of genomic regions in the mouse brain in vivo
Challenges and considerations for reproducibility of STARR-seq assays
Genome‐wide prediction of activating regulatory elements in rice by combining STARR‐seq with FACS
Uncovering the whole genome silencers of human cells via Ss-STARR-seq
📚 Books worth reading
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🔗 Related topics
- Enhancer (genetics) In genetics, an enhancer is a short (50–1500 bp) region of DNA that can be bound by proteins (activators) to increase the likelihood that transcription…
- DNase I hypersensitive site In genetics, DNase I hypersensitive sites (DHSs) are regions of chromatin that are sensitive to cleavage by the DNase I enzyme. In these specific regions…
- ChIP sequencing ChIP-sequencing, also known as ChIP-seq, is a method used to analyze protein interactions with DNA. ChIP-seq combines chromatin immunoprecipitation (ChIP)…
- Enhancer-FACS-seq Enhancer-FACS-seq (eFS), developed by the Bulyk lab at Brigham and Women’s Hospital and Harvard Medical School, is a highly parallel enhancer assay that…
- H3K14ac H3K14ac is an epigenetic modification to the DNA packaging protein Histone H3. It is a mark that indicates the acetylation at the 14th lysine residue of…
- H3K4me3 H3K4me3 is an epigenetic modification to the DNA packaging protein Histone H3 that indicates tri-methylation at the 4th lysine residue of the histone H3…
- H3K4me1 H3K4me1 is an epigenetic modification to the DNA packaging protein Histone H3. It is a mark that indicates the mono-methylation at the 4th lysine residue…
- H3K9ac H3K9ac is an epigenetic modification to the DNA packaging protein Histone H3. It is a mark that indicates the acetylation at the 9th lysine residue of…