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Everything about Repressor
Sort of RNA-binding protein in molecular genetics
In molecular genetics, a repressor is a DNA- or RNA-binding protein that inhibits the expression of one or more genes by binding to the operator or associated silencers. A DNA-binding repressor blocks the attachment of RNA polymerase to the promoter, thus preventing transcription of the genes into messenger RNA. An RNA-binding repressor binds to the mRNA and prevents translation of the mRNA into protein. This blocking or reducing of expression is called repression. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: RepressorA 5-minute orientation
- Skim a recent paper: SlERF.F12 modulates the transition to ripening in tomato fruit by recruiting the co-repressor TOPLESS and histone deacetylases to repress key ripening genesInfluential work since 2022
- Pick up a classic book: A genetic switchThe most-reprinted book on the subject
- Read the landmark paper: The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cellsCited 2,301 times
- Go sideways: InducerA closely related topic
- Go sideways: Regulator geneA closely related topic
📖 Definitions
Noun Anything that represses.
Noun Any protein that binds to DNA and thus regulates the expression of genes by decreasing the rate of transcription.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells
JAZ repressor proteins are targets of the SCFCOI1 complex during jasmonate signalling
Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis
FLOWERING LOCUS C Encodes a Novel MADS Domain Protein That Acts as a Repressor of Flowering
A transcriptional co-repressor that interacts with nuclear hormone receptors
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
A MicroRNA as a Translational Repressor of APETALA2 in Arabidopsis Flower Development
Histone Methyltransferase Activity of a Drosophila Polycomb Group Repressor Complex
🆕 Influential since 2022
SlERF.F12 modulates the transition to ripening in tomato fruit by recruiting the co-repressor TOPLESS and histone deacetylases to repress key ripening genes
Transcriptional repressor RST1 controls salt tolerance and grain yield in rice by regulating gene expression of asparagine synthetase
KAP1/TRIM28: Transcriptional Activator and/or Repressor of Viral and Cellular Programs?
MYB30 and MYB14 form a repressor–activator module with WRKY8 that controls stilbene biosynthesis in grapevine
Phosphorylation of the auxin signaling transcriptional repressor IAA15 by MPKs is required for the suppression of root development under drought stress in Arabidopsis
📚 Books worth reading
A genetic switchMark Ptashne, Klaus Dartmann · 1986- 📕Synthetic nucleic acids as inhibitors of gene expressionLevon Michael Khachigian · 2004
- 📕The 7 Å structure of a 434 repressor-operator complexJohn Earl Anderson · 1984
- 📕Transcriptional repression by polycomb-group proteinsIan F.G. King · 2004
- 📕The bacteriophage P1 bof proteinTimothy S. Schaefer · 1991
- 📕Cooperative binding of [lambda] repressor to its sites on DNAAnna Astromoff · 1992
- 📕Attivazione e repressione genica negli organismi superioriLidia Larizza · 1975
- 📕The binding specificity determinants of 434 repressorRobin Philip Wharton · 1985
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Inducer In molecular biology, an inducer is a molecule that regulates gene expression. An inducer functions in two ways; namely: By disabling repressors. The gene…
- Regulator gene In genetics, a regulator gene, regulator, or regulatory gene is a gene involved in controlling the expression of one or more other genes. Regulatory sequences…
- L-arabinose operon The L-arabinose operon, also called the ara or araBAD operon, is an operon required for the breakdown of the five-carbon sugar L-arabinose in Escherichia…
- Silencer (genetics) In genetics, a silencer is a DNA sequence capable of binding transcription regulation factors, called repressors. DNA contains genes and provides the template…
- PBAD promoter PBAD (systematically araBp) is a promoter found in bacteria and especially as part of plasmids used in laboratory studies. The promoter is a part of the…
- Gal operon The gal operon is a prokaryotic operon, which encodes enzymes necessary for galactose metabolism. Repression of gene expression for this operon works via…
- Operon In genetics, an operon is a functioning unit of DNA containing a cluster of genes under the control of a single promoter. The genes are transcribed together…
- Lac operon The lactose operon (lac operon) is an operon required for the transport and metabolism of lactose in E. coli and many other enteric bacteria. Although…