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Everything about Reading frame
Specific grouping of nucleotides into threes
In molecular biology, a reading frame is a specific choice out of the possible ways to read the sequence of nucleotides in a nucleic acid molecule as a sequence of triplets. Where these triplets equate to amino acids or stop signals during translation, they are called codons. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: Reading frameA 5-minute orientation
- Skim a recent paper: Standardized annotation of translated open reading framesInfluential work since 2022
- Pick up a classic book: If on a Winter's Night a TravelerThe most-reprinted book on the subject
- Read the landmark paper: Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19Cited 1,314 times
- Go sideways: Sense (molecular biology)A closely related topic
- Go sideways: Coding regionA closely related topic
📖 Definitions
Noun Any of three possible sequences of codons in which an RNA sequence could be translated.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
A perspective on mammalian upstream open reading frame function
Conserved Upstream Open Reading Frame Nascent Peptides That Control Translation
How translational accuracy influences reading frame maintenance
Maintaining the Ribosomal Reading Frame
Reading Frame Selection and Transfer RNA Anticodon Loop Stacking
The Definition of Open Reading Frame Revisited
🆕 Influential since 2022
Standardized annotation of translated open reading frames
The dark proteome: translation from noncanonical open reading frames
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames
mRNA reading frame maintenance during eukaryotic ribosome translocation
Small Open Reading Frame-Encoded Micro-Peptides: An Emerging Protein World
📚 Books worth reading
If on a Winter's Night a TravelerItalo Calvino · 1982
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Sense (molecular biology) In molecular biology and genetics, the sense of a nucleic acid molecule, particularly of a strand of DNA or RNA, refers to the nature of the roles of the…
- Coding region The coding region of a gene, also known as the coding DNA sequence (CDS), is the portion of a gene's DNA or RNA that codes for a protein. Studying the…
- Glossary of cellular and molecular biology (M–Z) This glossary of cellular and molecular biology is a list of definitions of terms and concepts commonly used in the study of cell biology, molecular biology…
- Ribosomal frameshift Ribosomal frameshifting, also known as translational frameshifting or translational recoding, is a biological phenomenon that occurs during translation…
- Genetic code Genetic code is a set of rules used by living cells to translate information encoded within genetic material (DNA or RNA sequences of nucleotide triplets…
- Directionality (molecular biology) Directionality, in molecular biology and biochemistry, is the end-to-end chemical orientation of a single strand of nucleic acid. In a single strand of…
- Stop codon In molecular biology, a stop codon (or termination codon) is a codon (nucleotide triplet within messenger RNA) that signals the termination of the translation…
- Translation (biology) Translation is the process in biological cells in which proteins are produced using RNA molecules as templates. The generated protein is a sequence of…