Everything about Pacemaker current

🧭 Start here: a 6-step reading path

1. Read the overview: Pacemaker currentA 5-minute orientation
2. Skim a recent paper: Pacemaker Induced Cardiomyopathy: An Overview of Current LiteratureInfluential work since 2022
3. Pick up a classic book: Treasure IslandThe most-reprinted book on the subject
4. Read the landmark paper: Queer Current and Pacemaker: The Hyperpolarization-Activated Cation Current in NeuronsCited 993 times
5. Go sideways: Dario DiFrancescoA closely related topic
6. Go sideways: HCN channelA closely related topic

🏆 Landmark papers (most cited)

• Queer Current and Pacemaker: The Hyperpolarization-Activated Cation Current in Neurons

  H-C Pape · 1996 · Annual Review of Physiology · 993 citations

• The Role of the Funny Current in Pacemaker Activity

  Dario DiFrancesco · 2010 · Circulation Research · 531 citations

• Interstitial cells of Cajal generate a rhythmic pacemaker current

  Lars Thomson, Tim L. Robinson, Jonathan C.F. Lee · 1998 · Nature Medicine · 376 citations

• Physiology and pharmacology of the cardiac pacemaker (“funny”) current

  Mirko Baruscotti, Annalisa Bucchi, Dario DiFrancesco · 2005 · Pharmacology & Therapeutics · 291 citations

• Pacemaker current (If) in the human sinoatrial node

  A. O. Verkerk, R. Wilders, M. M.G.J. van Borren · 2007 · European Heart Journal · 136 citations

• The cardiac pacemaker current

  Mirko Baruscotti, Andrea Barbuti, Annalisa Bucchi · 2010 · Journal of Molecular and Cellular Cardiology · 127 citations

• Pacemaker current i(f) in adult canine cardiac ventricular myocytes.

  H Yu, F Chang, I S Cohen · 1995 · The Journal of Physiology · 88 citations

• Pacemaker Channels Produce an Instantaneous Current

  Catherine Proenza, Damiano Angoli, Eugene Agranovich · 2002 · Journal of Biological Chemistry · 86 citations

🆕 Influential since 2022

• Pacemaker Induced Cardiomyopathy: An Overview of Current Literature

  Callan Gavaghan · 2022 · Current Cardiology Reviews · 43 citations

• Role of NaV1.6-mediated persistent sodium current and bursting-pacemaker properties in breathing rhythm generation

  Carlos A. da Silva, Cameron J. Grover, Maria Cristina D. Picardo · 2023 · Cell Reports · 16 citations

• Piezoelectric Energy Harvesting for Pacemaker Applications: Current State-of-the-Art, Materials, Design, and Alternative Technologies

  Diwakar Singh, Shubham Saurabh, Peidong Li · 2025 · ACS Biomaterials Science & Engineering · 16 citations

• Human Sinoatrial Node Pacemaker Activity: Role of the Slow Component of the Delayed Rectifier K+ Current, IKs

  Arie O. Verkerk, Ronald Wilders · 2023 · International Journal of Molecular Sciences · 11 citations

• The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells

  Colin H. Peters, Christian Rickert, Stefano Morotti · 2022 · Journal of General Physiology · 7 citations

📚 Books worth reading

• Treasure IslandRobert Louis Stevenson · 1880
• The deerslayerJames Fenimore Cooper · 1841
• The Strange Case of Dr. Jekyll and Mr. HydeRobert Louis Stevenson · 1875
• 📕Cardiology Today and TomorrowMayo Clinic. · 1995
• Cardiac resynchronization therapyDavid L. Hayes, Angelo Auricchio · 2008
• New arrhythmia technologiesPaul J. Wang · 2005
• Cardiovascular Diseases And Disorders SourcebookSandra J. Judd · 2004
• 📕Cardiac pacemakersRaul D. Mitrani · 1999

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics

• Dario DiFrancesco Dario DiFrancesco (born 10 February 1948) is a Professor Emeritus (Physiology) at the University of Milano. In 1979, he and collaborators discovered the…
• HCN channel Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are integral membrane proteins that serve as nonselective voltage-gated cation channels…
• HCN4 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 is a protein that in humans is encoded by the HCN4 gene. There are four…
• Sinoatrial node The sinoatrial node (also known as the sinuatrial node, SA node, sinus node or Keith–Flack node) is an oval shaped region of special cardiac muscle in…
• Cardiac action potential Unlike the action potential in skeletal muscle cells, the cardiac action potential is not initiated by nervous activity. Instead, it arises from a group…
• Pacemaker potential In the pacemaking cells of the heart (e.g., the sinoatrial node), the pacemaker potential (also called the pacemaker current) is the slow, positive increase…
• HCN2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 is a protein that in humans is encoded by the HCN2 gene. HCN2 has been…
• Diastolic depolarization In mammals, cardiac electrical activity originates from specialized myocytes of the sinoatrial node (SAN) which generate spontaneous and rhythmic action…