Everything about HCN2

🧭 Start here: a 6-step reading path

1. Read the overview: HCN2A 5-minute orientation
2. Skim a recent paper: Activation of CB1R alleviates central sensitization by regulating HCN2-pNR2B signaling in a chronic migraine rat modelInfluential work since 2022
3. Pick up a classic book: The poisoner's handbookThe most-reprinted book on the subject
4. Read the landmark paper: Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2Cited 460 times
5. Go sideways: HCN1A closely related topic
6. Go sideways: HCN4A closely related topic

🏆 Landmark papers (most cited)

• Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2

  Andreas Ludwig, Thomas Budde, Juliane Stieber · 2003 · The EMBO Journal · 460 citations

• HCN2 Ion Channels Play a Central Role in Inflammatory and Neuropathic Pain

  Edward C. Emery, Gareth T. Young, Esther M. Berrocoso · 2011 · Science · 332 citations

• Properties of Hyperpolarization-Activated Pacemaker Current Defined by Coassembly of Hcn1 and Hcn2 Subunits and Basal Modulation by Cyclic Nucleotide

  Shan Chen, Jing Wang, Steven A. Siegelbaum · 2001 · The Journal of General Physiology · 306 citations

• HCN2 and HCN1 Channels Govern the Regularity of Autonomous Pacemaking and Synaptic Resetting in Globus Pallidus Neurons

  C. Savio Chan, Ryuichi Shigemoto, Jeff N. Mercer · 2004 · The Journal of Neuroscience · 171 citations

• Retracted: Novel approaches for gene‐specific interference via manipulating actions of microRNAs: Examination on the pacemaker channel genes HCN2 and HCN4

  Jiening Xiao, Baofeng Yang, Huixian Lin · 2007 · Journal of Cellular Physiology · 157 citations

• Functional Heteromerization of HCN1 and HCN2 Pacemaker Channels

  Chris Ulens, Jan Tytgat · 2001 · Journal of Biological Chemistry · 150 citations

• Down-regulation of miR-1/miR-133 Contributes to Re-expression of Pacemaker Channel Genes HCN2 and HCN4 in Hypertrophic Heart*

  Xiaobin Luo, Huixian Lin, Zhengwei Pan · 2008 · Journal of Biological Chemistry · 144 citations

• Salt Bridges and Gating in the COOH-terminal Region of HCN2 and CNGA1 Channels

  Kimberley B. Craven, William N. Zagotta · 2004 · The Journal of General Physiology · 132 citations

🆕 Influential since 2022

• Activation of CB1R alleviates central sensitization by regulating HCN2-pNR2B signaling in a chronic migraine rat model

  Xiaoxu Zeng, Jia Mai, Hongjian Xie · 2023 · The Journal of Headache and Pain · 28 citations

• Thalamocortical Circuit Controls Neuropathic Pain via Up-regulation of HCN2 in the Ventral Posterolateral Thalamus

  Yi Yan, Mengye Zhu, Xuezhong Cao · 2022 · Neuroscience Bulletin · 27 citations

• HCN2 channel‐induced rescue of brain, eye, heart and gut teratogenesis caused by nicotine, ethanol and aberrant notch signalling

  Vaibhav P. Pai, Michael Levin · 2022 · Wound Repair and Regeneration · 26 citations

• PEX5R/Trip8b-HCN2 channel regulating neuroinflammation involved in perioperative neurocognitive disorders

  Feng Xu, Yafeng Wang, Linlin Han · 2022 · Cell & Bioscience · 20 citations

• Up-regulation of HCN2 channels in a thalamocortical circuit mediates allodynia in mice

  Jun-Ma Yu, Rui Hu, Yu Mao · 2022 · National Science Review · 19 citations

📚 Books worth reading

• The poisoner's handbookDeborah Blum · 2010
• 📕HCN2-Schrittmacherkan̈aleFriederike Winkhaus · 2011
• 📕Untersuchungen über das Gleichgewicht NH₃+CO = HCN+H₂OWalter Schültze · 1927
• 📕Hochauflösende Spektroskopie interstellarer MoleküleMichael Olberg · 1984
• 📕Etude et réalisation d'un laser HCN-H₂OJ.-M Lourtioz
• 📕The Acute toxicity of brief exposures to HF, HCl, NO₂ and HCN singly and in combination with CO · 1971
• 📕The acute toxicity of brief exposures to HF, HCl, NO2 and HCN singly and in combination with COE. A. Higgins, United States. Office of Aviation Medicine · 1971
• 📕Rate coefficients for reactions of ethynyl radical (C₂H) with HCN and CH₃CNRay J. Hoobler · 1997

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics

• HCN1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 is a protein that in humans is encoded by the HCN1 gene. Hyperpolarization-activa…
• HCN4 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 is a protein that in humans is encoded by the HCN4 gene. There are four…
• HCN3 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 is a protein that in humans is encoded by the HCN3 gene. Cyclic nucleotide–gated…
• HCN channel Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are integral membrane proteins that serve as nonselective voltage-gated cation channels…
• Cyclic nucleotide-gated channel alpha 2 Cyclic nucleotide gated channel alpha 2, also known as CNGA2, is a human gene encoding an ion channel protein. Cyclic nucleotide-gated ion channel GRCh38:…
• Cyclic nucleotide-gated channel alpha 3 Cyclic nucleotide-gated cation channel alpha-3 is a protein that in humans is encoded by the CNGA3 gene. This gene encodes a member of the cyclic nucleotide-gat…
• ASIC2 Acid-sensing ion channel 2 (ASIC2) also known as amiloride-sensitive cation channel 1, neuronal (ACCN1) or brain sodium channel 1 (BNaC1) is a protein…
• KCNJ9 G protein-activated inward rectifier potassium channel 3 is a protein that in humans is encoded by the KCNJ9 gene. Potassium channels are present in most…