Everything about Missing heritability problem

🧭 Start here: a 6-step reading path

1. Read the overview: Missing heritability problemA 5-minute orientation
2. Skim a recent paper: The problem with genetic heritability estimates in psychiatry: ‘missing heritability’ or missed cross-cultural environmental variation?Influential work since 2022
3. Read the landmark paper: Epigenetic Inheritance and the Missing Heritability ProblemCited 286 times
4. Go sideways: Genome-wide complex trait analysisA closely related topic
5. Go sideways: Complex traitsA closely related topic

🏆 Landmark papers (most cited)

• Epigenetic Inheritance and the Missing Heritability Problem

  Montgomery Slatkin · 2009 · Genetics · 286 citations

• Solving the missing heritability problem

  Alexander I. Young · 2019 · PLOS Genetics · 224 citations

• Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the “Missing Heritability” Problem

  Kathrin Klein, Ulrich M. Zanger · 2013 · Frontiers in Genetics · 200 citations

• The Human Microbiome and the Missing Heritability Problem

  Santiago Sandoval-Motta, Maximino Aldana, Esperanza Martínez-Romero · 2017 · Frontiers in Genetics · 89 citations

• Limitations of GCTA as a solution to the missing heritability problem

  Siddharth Krishna Kumar, Marcus W. Feldman, David H. Rehkopf · 2015 · Proceedings of the National Academy of Sciences · 81 citations

• Three legs of the missing heritability problem

  Lucas J. Matthews, Eric Turkheimer · 2022 · Studies in History and Philosophy of Science · 61 citations

• Dissolving the Missing Heritability Problem

  Pierrick Bourrat, Qiaoying Lu · 2017 · Philosophy of Science · 28 citations

• Asthma and the Missing Heritability Problem: Necessity for Multiomics Approaches in Determining Accurate Risk Profiles

  Tracy Augustine, Mohammad Ameen Al-Aghbar, Moza Al-Kowari · 2022 · Frontiers in Immunology · 25 citations

🆕 Influential since 2022

• The problem with genetic heritability estimates in psychiatry: ‘missing heritability’ or missed cross-cultural environmental variation?

  George Gillett · 2024 · Psychiatry Research · 1 citations

📚 Books worth reading

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🔗 Related topics

• Genome-wide complex trait analysis Genome-wide complex trait analysis (GCTA) or genome-based restricted maximum likelihood (GREML) is a statistical method for heritability estimation in…
• Complex traits Complex traits, also known as polygenic or multigenic traits, are phenotypes determined by the interaction of multiple genetic and environmental factors…
• Genome-wide association study In genomics, a genome-wide association study (GWA study, or GWAS), is an observational study of a genome-wide set of genetic variants in different individuals…
• Genetic correlation In multivariate quantitative genetics, a genetic correlation (denoted r g {\displaystyle r_{g}} or r a {\displaystyle r_{a}} ) is the proportion of variance…
• Heritability Heritability is a statistic used in the fields of breeding and genetics that estimates the degree of variation in a phenotypic trait in a population that…
• Behavioural genetics Behavioural genetics, also referred to as behaviour genetics, is a field of scientific research that uses genetic methods to investigate the nature and…
• Predictive genomics Predictive genomics is at the intersection of multiple disciplines: predictive medicine, personal genomics and translational bioinformatics. Specifically…
• Linkage disequilibrium score regression In statistical genetics, linkage disequilibrium score regression (LDSR or LDSC) is a technique that aims to quantify the separate contributions of polygenic…