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Everything about Complex traits
Genetic trait
Complex traits, also known as polygenic or multigenic traits, are phenotypes determined by the interaction of multiple genetic and environmental factors. A central goal of contemporary genetics research is to understand the molecular mechanisms by which genetic variation influences complex traits. Examples of complex traits in humans include height; intelligence and cognitive function; body-mass index; blood pressure; and risk for complex diseases such as diabetes, heart disease, Alzheimer's disease, and schizophrenia. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: Complex traitsA 5-minute orientation
- Skim a recent paper: Systematic differences in discovery of genetic effects on gene expression and complex traitsInfluential work since 2022
- Pick up a classic book: AntifragileThe most-reprinted book on the subject
- Read the landmark paper: Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseasesCited 8,186 times
- Go sideways: Missing heritability problemA closely related topic
- Go sideways: Genome-wide association studyA closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
GCTA: A Tool for Genome-wide Complex Trait Analysis
TASSEL: software for association mapping of complex traits in diverse samples
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
🆕 Influential since 2022
Systematic differences in discovery of genetic effects on gene expression and complex traits
Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data
Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases
Spatially resolved mapping of cells associated with human complex traits
Genetic and molecular architecture of complex traits
📚 Books worth reading
AntifragileNassim Nicholas Taleb, Genís Sánchez Barberán · 2012- 📕Challenges of Governance in a Complex WorldPeter Ho · 2018
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Missing heritability problem In genetics, the missing heritability problem refers to a difference between heritability estimates obtained from early genome-wide association studies…
- Genome-wide association study In genomics, a genome-wide association study (GWA study, or GWAS), is an observational study of a genome-wide set of genetic variants in different individuals…
- Fine-mapping Fine-mapping is a set of methods in genetics used to identify the genetic variant or variants, often single-nucleotide polymorphisms (SNPs), most likely…
- Expression quantitative trait loci An expression quantitative trait locus (eQTL) is a type of quantitative trait locus (QTL), a genomic locus (region of DNA) that is associated with phenotypic…
- Quantitative trait locus A quantitative trait locus (QTL) is a genomic locus wherein sequence variation correlates with variation of a quantitative trait. QTLs are mapped by identifying…
- Transcriptome-wide association study Transcriptome-wide association study (TWAS) is a genetic methodology that can be used to compare the genetic components of gene expression and the genetic…
- Genetic architecture Genetic architecture refers to the underlying genetic basis of a phenotypic trait and its variational properties. Phenotypic variation for quantitative…
- Protein quantitative trait loci Protein quantitative trait loci (pQTL) are regions in the genome associated with variation in protein expression levels. Since proteins are the primary…