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Everything about Fine-mapping
Set of methods in genetics
Fine-mapping is a set of methods in genetics used to identify the genetic variant or variants, often single-nucleotide polymorphisms (SNPs), most likely to explain an observed association between a genetic locus and a phenotype. It is commonly used during genetic association studies, including quantitative trait locus (QTL) analyses and genome-wide association studies (GWAS). Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: Fine-mappingA 5-minute orientation
- Skim a recent paper: Fine-mapping from summary data with the “Sum of Single Effects” modelInfluential work since 2022
- Pick up a classic book: Mapping a city: Ausstellung Hamburg-Kartierung im Hamburger Kunstverein 2003/2004The most-reprinted book on the subject
- Read the landmark paper: Probabilistic fine-mapping of transcriptome-wide association studiesCited 434 times
- Go sideways: Association mappingA closely related topic
- Go sideways: Genome-wide association studyA closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Probabilistic fine-mapping of transcriptome-wide association studies
Mini-UAV-Borne LIDAR for Fine-Scale Mapping
Strategies for fine-mapping complex traits
Coalescent-Based Association Mapping and Fine Mapping of Complex Trait Loci
Fine mapping of human HOX gene clusters
Improving fine-mapping by modeling infinitesimal effects
Fine-mapping genetic associations
Fine mapping of an immunoglobulin gene activator.
🆕 Influential since 2022
Fine-mapping from summary data with the “Sum of Single Effects” model
Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores
Multi-ancestry meta-analysis and fine-mapping in Alzheimer’s disease
Mapping fine-scale building heights in urban agglomeration with spaceborne lidar
Towards improved fine-mapping of candidate causal variants
📚 Books worth reading
Mapping a city: Ausstellung Hamburg-Kartierung im Hamburger Kunstverein 2003/2004Denis Cosgrove, Tom McDonough · 2004- 📕Ottoman WorldLeonora Navari · 1998
International Library of PsychologyRoutledge · 1999- 📕[Amending section of Revised Statutes on regulation of steam vessels.]United States. Congress. Senate. Committee on Commerce
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Association mapping In genetics, association mapping, also known as "linkage disequilibrium mapping", is a method of mapping quantitative trait loci (QTLs) that takes advantage…
- Genome-wide association study In genomics, a genome-wide association study (GWA study, or GWAS), is an observational study of a genome-wide set of genetic variants in different individuals…
- Expression quantitative trait loci An expression quantitative trait locus (eQTL) is a type of quantitative trait locus (QTL), a genomic locus (region of DNA) that is associated with phenotypic…
- Genetic association Genetic association is when one or more genotypes within a population co-occur with a phenotypic trait more often than would be expected by chance occurrence…
- Complex traits Complex traits, also known as polygenic or multigenic traits, are phenotypes determined by the interaction of multiple genetic and environmental factors…
- Tag SNP A tag SNP is a representative single nucleotide polymorphism (SNP) in a region of the genome with high linkage disequilibrium that represents a group of…
- Quantitative trait locus A quantitative trait locus (QTL) is a genomic locus wherein sequence variation correlates with variation of a quantitative trait. QTLs are mapped by identifying…
- Single-nucleotide polymorphism In genetics and bioinformatics, a single-nucleotide polymorphism (SNP /snɪp/; plural SNPs /snɪps/) is a germline substitution of a single nucleotide at…