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Everything about Tag SNP
A tag SNP is a representative single nucleotide polymorphism (SNP) in a region of the genome with high linkage disequilibrium that represents a group of SNPs called a haplotype. It is possible to identify genetic variation and association to phenotypes without genotyping every SNP in a chromosomal region. This reduces the expense and time of mapping genome areas associated with disease, since it eliminates the need to study every individual SNP. Tag SNPs are useful in whole-genome SNP association studies in which hundreds of thousands of SNPs across the entire genome are genotyped. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: Tag SNPA 5-minute orientation
- Skim a recent paper: LmTag: functional-enrichment and imputation-aware tag SNP selection for population-specific genotyping arraysInfluential work since 2022
- Pick up a classic book: Cancer gene profilingThe most-reprinted book on the subject
- Read the landmark paper: Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1Cited 1,052 times
- Go sideways: HaploviewA closely related topic
- Go sideways: Genetic associationA closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21
Identification of SNP and SSR markers in eggplant using RAD tag sequencing
Tag SNP selection for association studies
Haplotype Block Partitioning and Tag SNP Selection Using Genotype Data and Their Applications to Association Studies
HapBlock: haplotype block partitioning and tag SNP selection software using a set of dynamic programming algorithms
Tag SNP selection in genotype data for maximizing SNP prediction accuracy
Power to Detect Risk Alleles Using Genome-Wide Tag SNP Panels
🆕 Influential since 2022
📚 Books worth reading
Cancer gene profilingRobert Grützmann, Christian Pilarsky · 2009
Single nucleotide polymorphismsAnton A. Komar · 2009
Principles of gene manipulation and genomicsS. B. Primrose · 2006
Analysis of complex disease association studiesEleftheria Zeggini · 2010
Clinical bioinformaticsR. J. Trent · 2007
Forensic DNA typing protocolsAngel Carracedo · 2005- 📕Plant genotypingJacqueline Batley · 2015
- 📕Development of Single Molecule Electronic SNP Assays using Polymer Tagged Nucleotides and Nanopore DetectionYoungjin Cho · 2018
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Haploview Haploview is a commonly used bioinformatics software which is designed to analyze and visualize patterns of linkage disequilibrium (LD) in genetic data…
- Genetic association Genetic association is when one or more genotypes within a population co-occur with a phenotypic trait more often than would be expected by chance occurrence…
- Linkage disequilibrium Linkage disequilibrium, often abbreviated to LD, is a term in population genetics referring to the association of genes, usually linked genes, in a population…
- Association mapping In genetics, association mapping, also known as "linkage disequilibrium mapping", is a method of mapping quantitative trait loci (QTLs) that takes advantage…
- Imputation (genetics) In genetics, genotype imputation is a statistical method used to infer unobserved or missing genotypes. It is achieved by using patterns of genetic variation…
- Fine-mapping Fine-mapping is a set of methods in genetics used to identify the genetic variant or variants, often single-nucleotide polymorphisms (SNPs), most likely…
- Single-nucleotide polymorphism In genetics and bioinformatics, a single-nucleotide polymorphism (SNP /snɪp/; plural SNPs /snɪps/) is a germline substitution of a single nucleotide at…
- International HapMap Project The International HapMap Project is an organization that aimed to develop a haplotype map (HapMap) of the human genome, to describe the common patterns…