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Everything about MicroRNA
Small non-coding ribonucleic acid molecule
Micro ribonucleic acid are small, single-stranded, non-coding RNA molecules containing 21–23 nucleotides. Found in plants, animals, and even some viruses, microRNAs are involved in RNA silencing and post-transcriptional regulation of gene expression. miRNAs base-pair to complementary sequences in messenger RNA (mRNA) molecules, then silence these mRNA molecules by one or more of the following processes:Cleaving the mRNA strand into two pieces. Destabilizing the mRNA by shortening its poly(A) tail. Reducing translation of the mRNA into proteins. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: MicroRNAA 5-minute orientation
- Skim a recent paper: MicroRNA-Based Diagnosis and TherapyInfluential work since 2022
- Pick up a classic book: MicroRNAsThe most-reprinted book on the subject
- Read the landmark paper: Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA TargetsCited 10,064 times
- Go sideways: Mir-145A closely related topic
- Go sideways: Mir-124 microRNA precursor familyA closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🏆 Landmark papers (most cited)
Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets
MicroRNA expression profiles classify human cancers
Natural RNA circles function as efficient microRNA sponges
MicroRNA signatures in human cancers
Predicting effective microRNA target sites in mammalian mRNAs
Regulation of microRNA biogenesis
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
miRBase: from microRNA sequences to function
🆕 Influential since 2022
MicroRNA-Based Diagnosis and Therapy
MicroRNA: trends in clinical trials of cancer diagnosis and therapy strategies
Trials and Tribulations of MicroRNA Therapeutics
miRTarBase 2025: updates to the collection of experimentally validated microRNA–target interactions
MicroRNA in cancer therapy: breakthroughs and challenges in early clinical applications
📚 Books worth reading
MicroRNAsKrishnarao Appasani · 2007
MetagenomicsWolfgang R. Streit, Rolf Daniel · 2010
Regulation of gene expression by small RNAsJohn J. Rossi · 2008
Rna Technologies And Their ApplicationsJan Barciszewski · 2010
MicroRNAs in MedicineCharles H. Lawrie · 2013
microRNA : Basic ScienceGaetano Santulli · 2015
microRNA : Medical EvidenceGaetano Santulli · 2015
MicroRNAs and the immune systemSilvia Monticelli · 2010
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Mir-145 In molecular biology, mir-145 microRNA is a short RNA molecule that in humans is encoded by the MIR145 gene. MicroRNAs function to regulate the expression…
- Mir-124 microRNA precursor family The miR-124 microRNA precursor is a small non-coding RNA molecule that has been identified in flies (MI0000373), nematode worms (MI0000302), mouse (MI0000150)…
- Drosha Drosha is a Class 2 ribonuclease III enzyme that in humans is encoded by the DROSHA (formerly RNASEN) gene. It is the primary nuclease that executes the…
- Let-7 microRNA family The Let-7 microRNA precursor gives rise to let-7, a microRNA (miRNA) involved in control of stem-cell division and differentiation. let-7, short for "lethal-7"…
- Mir-26 microRNA precursor family The miR-26 microRNA is a small non-coding RNA that is involved in regulating gene expression. The miR-26 family is composed of miR-26a-1, miR-26a-2 and…
- Dicer Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. Being part of the…
- Microprocessor complex The microprocessor complex is a protein complex involved in the early stages of processing microRNA (miRNA) and RNA interference (RNAi) in animal cells…
- MiR-155 MiR-155 is a microRNA that in humans is encoded by the MIR155 host gene or MIR155HG. MiR-155 plays a role in various physiological and pathological processes…