Live briefing
Everything about Drosha
Ribonuclease III enzyme
Drosha is a Class 2 ribonuclease III enzyme that in humans is encoded by the DROSHA gene. It is the primary nuclease that executes the initiation step of miRNA processing in the nucleus. It works closely with DGCR8 and in correlation with Dicer. It has been found significant in clinical knowledge for cancer prognosis and HIV-1 replication. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: DroshaA 5-minute orientation
- Skim a recent paper: The microRNA processorDROSHAis a candidate gene for a severe progressive neurological disorderInfluential work since 2022
- Pick up a classic book: RNA silencingThe most-reprinted book on the subject
- Read the landmark paper: The nuclear RNase III Drosha initiates microRNA processingCited 4,006 times
- Go sideways: Microprocessor complexA closely related topic
- Go sideways: DicerA closely related topic
📖 Definitions
Noun An RNA-specific endoribonuclease
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
The nuclear RNase III Drosha initiates microRNA processing
The Drosha-DGCR8 complex in primary microRNA processing
Intronic microRNA precursors that bypass Drosha processing
Molecular Basis for the Recognition of Primary microRNAs by the Drosha-DGCR8 Complex
SMAD proteins control DROSHA-mediated microRNA maturation
Role of Dicer and Drosha for Endothelial MicroRNA Expression and Angiogenesis
Dicer, Drosha, and Outcomes in Patients with Ovarian Cancer
Site-specific DICER and DROSHA RNA products control the DNA-damage response
🆕 Influential since 2022
The microRNA processorDROSHAis a candidate gene for a severe progressive neurological disorder
Consequences of depleting TNRC6, AGO, and DROSHA proteins on expression of microRNAs
YB-1 Recruits Drosha to Promote Splicing of pri-miR-192 to Mediate the Proangiogenic Effects of H 2 S
Role of the proline-rich disordered domain of DROSHA in intronic microRNA processing
Drosha-dependent microRNAs modulate FUS-mediated neurodegeneration in vivo
📚 Books worth reading
RNA silencingGordon Carmichael · 2005- 📕miRNA maturationChristoph Arenz · 2014
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Microprocessor complex The microprocessor complex is a protein complex involved in the early stages of processing microRNA (miRNA) and RNA interference (RNAi) in animal cells…
- Dicer Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. Being part of the…
- Ribonuclease III Ribonuclease III (RNase III or RNase C) (BRENDA 3.1.26.3) is a type of ribonuclease that recognizes dsRNA and cleaves it at specific targeted locations…
- Microprocessor complex subunit DGCR8 The microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) is a protein that in humans is encoded by the DGCR8 gene. In other animals…
- DCL1 DCL1 (an abbreviation of Dicer-like 1) is a gene in plants that codes for the DCL1 protein, a ribonuclease III enzyme involved in processing double-stranded…
- MIR141 MicroRNA 141 is a non-coding RNA molecule that in humans is encoded by the MIR141 gene. microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are…
- MicroRNA 203a MicroRNA 203a is a small RNA that in humans is encoded by the preMIR203A gene. microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved…
- MicroRNA 148a MicroRNA 148a is a miRNA that in humans is encoded by the MIR148A gene. microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transc…