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Everything about HOTTIP
In molecular biology, HOTTIP is a long non-coding RNA. The gene encoding HOTTIP is located at the 5′ tip of the HOXA locus, and coordinates the activation of several of the 5′ HOXA genes. The non-coding RNA is brought into close proximity with the HOXA genes by chromosomal looping. HOTTIP binds to the WDR5 protein, which forms a complex with the histone methyltransferase protein MLL. This targets the WDR5-MLL complex to the HOXA region and results in H3K4 methylation and transcriptional activation of the HOXA locus. More recently, HOTTIP has been shown to play a role in hepatocellular carcinoma (HCC) progression. HOTTIP expression levels predict metastasis and poor disease outcome in HCC patients. HOTTIP has been shown to be transcriptionally regulated by a transcriptional coactivator PSIP1/p52 Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: HOTTIPA 5-minute orientation
- Skim a recent paper: M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-κB pathwayInfluential work since 2022
- Pick up a classic book: Hottips for teachersThe most-reprinted book on the subject
- Read the landmark paper: Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patientsCited 349 times
- Go sideways: PSIP1A closely related topic
- Go sideways: HOTAIRA closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🗂️ The subject at a glance
No outline available.
🏆 Landmark papers (most cited)
Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients
Exosomal long noncoding RNA HOTTIP as potential novel diagnostic and prognostic biomarker test for gastric cancer
The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer
LncRNA HOTTIP modulates cancer stem cell properties in human pancreatic cancer by regulating HOXA9
HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice
Long non-coding RNA HOTTIP enhances IL-6 expression to potentiate immune escape of ovarian cancer cells by upregulating the expression of PD-L1 in neutrophils
HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia
fMiRNA-192 and miRNA-204 Directly Suppress lncRNA HOTTIP and Interrupt GLS1-Mediated Glutaminolysis in Hepatocellular Carcinoma
🆕 Influential since 2022
M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-κB pathway
Long non-coding RNA PAARH promotes hepatocellular carcinoma progression and angiogenesis via upregulating HOTTIP and activating HIF-1α/VEGF signaling
Fusobacterium nucleatum‐induced exosomal HOTTIP promotes gastric cancer progression through the microRNA‐885‐3p/EphB2 axis
Solamargine inhibits the growth of hepatocellular carcinoma and enhances the anticancer effect of sorafenib by regulating HOTTIP‐TUG1/miR‐4726‐5p/MUC1 pathway
HOTTIP downregulation reduces neuronal damage and microglial activation in Parkinson's disease cell and mouse models
📚 Books worth reading
Hottips for teachersRobert Abernathy, Mark Reardon · 2001
HotTips for speakersRob Abernathy, Mark Reardon · 2001
HotTips for facilitatorsRob Abernathy, Mark Reardon · 2002
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- PSIP1 PC4 and SFRS1 interacting protein 1, also known as lens epithelium-derived growth factor (LEDGF/p75), dense fine speckles 70kD protein (DFS 70) or transcription…
- HOTAIR HOTAIR (for HOX transcript antisense RNA) is a human gene located between HOXC11 and HOXC12 on chromosome 12. It is the first example of an RNA expressed…
- Small nucleolar RNA host gene 1 Small nucleolar RNA host gene 1 is a non-protein coding RNA that in humans is encoded by the SNHG1 gene. This locus represents a small nucleolar RNA host…
- Long non-coding RNA Long non-coding RNAs (long ncRNAs, lncRNA) are a type of RNA, generally defined as transcripts of more than 200 nucleotides that are not translated into…
- Non-coding RNA A non-coding RNA (ncRNA) is a functional RNA molecule that is not translated into a protein. The DNA sequence from which a functional non-coding RNA is…
- Colon cancer associated transcript 1 Colon cancer associated transcript 1 is a long non-coding RNA that, in humans, is encoded by the CCAT1 gene. This gene produces a long non-coding RNA that…
- Mir-26 microRNA precursor family The miR-26 microRNA is a small non-coding RNA that is involved in regulating gene expression. The miR-26 family is composed of miR-26a-1, miR-26a-2 and…
- EMP3 Epithelial membrane protein 3 (EMP3) is a trans-membrane signaling molecule that is encoded by the myelin-related gene EMP3. EMP3 is a member of the peripheral…