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Everything about PSIP1
Protein found in humans
PC4 and SFRS1 interacting protein 1, also known as lens epithelium-derived growth factor (LEDGF/p75), dense fine speckles 70kD protein or transcriptional coactivator p75/p52, is a protein that in humans is encoded by the PSIP1 gene. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: PSIP1A 5-minute orientation
- Skim a recent paper: PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integrityInfluential work since 2022
- Pick up a classic book: Medium term development strategy, 1999-2001The most-reprinted book on the subject
- Read the landmark paper: Psip1/Ledgf p52 Binds Methylated Histone H3K36 and Splicing Factors and Contributes to the Regulation of Alternative SplicingCited 350 times
- Go sideways: HDGFL3A closely related topic
- Go sideways: HIV integrationA closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Psip1/Ledgf p52 Binds Methylated Histone H3K36 and Splicing Factors and Contributes to the Regulation of Alternative Splicing
Role of PSIP1/LEDGF/p75 in Lentiviral Infectivity and Integration Targeting
Nucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domain
A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75
Disruption of Ledgf/Psip1 Results in Perinatal Mortality and Homeotic Skeletal Transformations
TALEN Knockout of the PSIP1 Gene in Human Cells: Analyses of HIV-1 Replication and Allosteric Integrase Inhibitor Mechanism
Psip1/Ledgf p75 restrainsHoxgene expression by recruiting both trithorax and polycomb group proteins
PSIP1/p75 promotes tumorigenicity in breast cancer cells by promoting the transcription of cell cycle genes
🆕 Influential since 2022
PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integrity
CircRNA‐mTOR Promotes Hepatocellular Carcinoma Progression and Lenvatinib Resistance Through the PSIP1/c‐Myc Axis
Identifying PSIP1 as a critical R-loop regulator in osteosarcoma via machine-learning and multi-omics analysis
A dual role for PSIP1/LEDGF in T cell acute lymphoblastic leukemia
Role of LEDGF/p75 (PSIP1) in oncogenesis. Insights in molecular mechanism and therapeutic potential
📚 Books worth reading
- 📕Medium term development strategy, 1999-2001Solomon Islands. Ministry of National Planning & Development · 1998
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
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