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Everything about Gene expression profiling
Detection of mRNA molecules
In the field of molecular biology, gene expression profiling is the measurement of the activity of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: Gene expression profilingA 5-minute orientation
- Skim a recent paper: Spatial Transcriptomics: Emerging Technologies in Tissue Gene Expression ProfilingInfluential work since 2022
- Pick up a classic book: Microarray Methods and ProtocolsThe most-reprinted book on the subject
- Read the landmark paper: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profilesCited 51,039 times
- Go sideways: Expression AtlasA closely related topic
- Go sideways: Functional genomicsA closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🏆 Landmark papers (most cited)
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses
Gene expression profiling predicts clinical outcome of breast cancer
🆕 Influential since 2022
Spatial Transcriptomics: Emerging Technologies in Tissue Gene Expression Profiling
Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses
Targeted gene expression profiling for accurate endometrial receptivity testing
MALAT1-regulated gene expression profiling in lung cancer cell lines
Deep profiling of gene expression across 18 human cancers
📚 Books worth reading
Microarray Methods and ProtocolsRobert S. Matson · 2008
Statistical Analysis of Gene Expression Microarray DataTerry Speed · 2003
Computational intelligence and pattern analysis in biology informaticsUjjwal Maulik · 2010
Microarray innovationsGary Hardiman · 2008
Metabolic profilingGeorge G. Harrigan, Royston Goodacre · 2003
MicroarraysHans-Joachim Muller, Hans-Joachim Müller · 2005
Cancer gene profilingRobert Grützmann, Christian Pilarsky · 2009
Differential display methods and protocolsPeng Liang, Arthur B. Pardee · 1997
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Expression Atlas The Expression Atlas is a database maintained by the European Bioinformatics Institute that provides information on gene expression patterns from RNA-Seq…
- Functional genomics Functional genomics is a field of molecular biology that attempts to describe gene (and protein) functions and interactions. Functional genomics make use…
- Transcriptome The transcriptome is the set of all RNA molecules (transcripts) in a cell or a population of cells. It includes all of the functional RNA molecules and…
- Microarray analysis techniques Microarray analysis techniques are used in interpreting the data generated from experiments on DNA (Gene chip analysis), RNA, and protein microarrays,…
- Transcriptomics technologies Transcriptomics technologies are the techniques used to study an organism's transcriptome, the sum of all of its RNA transcripts. The information content…
- DNA microarray A DNA microarray (also commonly known as a DNA chip or biochip) is a collection of microscopic DNA spots attached to a solid surface. Scientists use DNA…
- RNA-Seq RNA-Seq (short for RNA sequencing) is a next-generation sequencing (NGS) technique used to quantify and identify RNA molecules in a biological sample,…
- Gene expression Gene expression is the process by which the information contained within a gene is used to produce a functional gene product, such as a protein or a functional…