Everything about Gene expression
Conversion of a gene's sequence into a mature gene product or products
Gene expression is the process by which the information contained within a gene is used to produce a functional gene product, such as a protein or a functional RNA molecule. This process involves multiple steps, including the transcription of the gene's sequence into RNA. For protein-coding genes, this RNA is further translated into a chain of amino acids that folds into a protein, while for non-coding genes, the resulting RNA itself serves a functional role in the cell. Gene expression enables cells to utilize the genetic information in genes to carry out a wide range of biological functions. While expression levels can be regulated in response to cellular needs and environmental changes, some genes are expressed continuously with little variation. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: Gene expressionA 5-minute orientation
- Skim a recent paper: Cell type and gene expression deconvolution with BayesPrism enables Bayesian integrative analysis across bulk and single-cell RNA sequencing in oncologyInfluential work since 2022
- Pick up a classic book: Molecular biology of the geneThe most-reprinted book on the subject
- Read the landmark paper: Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodCited 168,092 times
- Go sideways: Transcription (biology)A closely related topic
- Go sideways: Transcriptional regulationA closely related topic
📖 Definitions
Noun The transcription and translation of a gene into messenger RNA and thus into a protein; it may be lesser or greater depending on many epigenetic factors.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
edgeR : a Bioconductor package for differential expression analysis of digital gene expression data
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
SCANPY: large-scale single-cell gene expression data analysis
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
🆕 Influential since 2022
Cell type and gene expression deconvolution with BayesPrism enables Bayesian integrative analysis across bulk and single-cell RNA sequencing in oncology
NCBI GEO: archive for gene expression and epigenomics data sets: 23-year update
Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis
Systematic differences in discovery of genetic effects on gene expression and complex traits
📚 Books worth reading
Molecular biology of the geneJames D. Watson, Nancy H. Hopkins · 1965
The Extended PhenotypeRichard Dawkins, Wolfgang Mayer · 1981
Eukaryotic Gene RegulationGerald M. Kolodny · 1980
The epigenetics revolutionNessa Carey · 2011- 📕Rattazzi Isozymes - Current Topics in Biological & Medical ResearchMC RATTAZZI · 1977
- 📕BiotechnologyJean A. Larson · 1988
Nutrient-gene interactions in health and diseaseCarolyn D. Berdanier · 2001
Peroxisomal disorders and regulation of genesFrank Roels · 2003
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Transcription (biology) Transcription is the process of duplicating a segment of DNA into RNA for the purpose of gene expression. Some segments of DNA are transcribed into RNA…
- Transcriptional regulation In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby…
- Eukaryotic transcription Eukaryotic transcription is the elaborate process that eukaryotic cells use to copy genetic information stored in DNA into units of transportable complementary…
- Regulation of gene expression Regulation of gene expression, or gene regulation, includes a wide range of mechanisms that are used by cells to increase or decrease the production of…
- Promoter (genetics) In genetics, a promoter is a sequence of DNA to which proteins bind to initiate transcription of a single RNA transcript from the DNA downstream of the…
- Gene structure Gene structure is the organisation of specialised sequence elements within a gene. Genes contain most of the information necessary for living cells to…
- Post-transcriptional regulation Post-transcriptional regulation is the control of gene expression at the RNA level. It occurs once the RNA polymerase has been attached to the gene's promoter…
- Regulatory sequence A regulatory sequence is a segment of a nucleic acid molecule which is capable of increasing or decreasing the expression of specific genes within an organism…