Everything about Exon
Region of a transcribed gene present in the final functional mRNA molecule
An exon is any part of a gene that will form a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing. The term exon refers to both the DNA sequence within a gene and to the corresponding sequence in RNA transcripts. In RNA splicing, introns are removed and exons are covalently joined to one another as part of generating the mature RNA. Just as the entire set of genes for a species constitutes the genome, the entire set of exons constitutes the exome. Wikipedia →
🧠Start here: a 6-step reading path
- Read the overview: ExonA 5-minute orientation
- Skim a recent paper: TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13AInfluential work since 2022
- Pick up a classic book: Exons, introns, and talking genesThe most-reprinted book on the subject
- Read the landmark paper: Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic MiceCited 2,719 times
- Go sideways: IntronA closely related topic
- Go sideways: RNA splicingA closely related topic
đź“– Definitions
Noun An officer of the King's Body Guard of the Yeomen of the Guard.
Noun A region of a transcribed gene present in the final functional RNA molecule.
Noun ↑ "The notion of the cistron [i.e., gene] ... must be replaced by that of a transcription unit containing regions which will be lost from the mature messenger – which I suggest we call introns (for intragenic regions) – alternating with regions which will be expressed – exons." (Walter Gilbert 1978)
🏆 Landmark papers (most cited)
Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice
Exon-intron circular RNAs regulate transcription in the nucleus
Complementary Sequence-Mediated Exon Circularization
The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin ÎĽ chain gene
Genome-Wide Survey of Human Alternative Pre-mRNA Splicing with Exon Junction Microarrays
JAK2 Exon 12 Mutations in Polycythemia Vera and Idiopathic Erythrocytosis
Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking
🆕 Influential since 2022
TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A
Amivantamab plus Chemotherapy in NSCLC with EGFR Exon 20 Insertions
AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or MetastaticNon–Small-Cell Lung Cancer With EGFR Exon 19 Deletion or L858R Mutations
Exon architecture controls mRNA m 6 A suppression and gene expression
Exclusion of m6A from splice-site proximal regions by the exon junction complex dictates m6A topologies and mRNA stability
đź“š Books worth reading
Exons, introns, and talking genesChristopher Wills · 1991
Genomic Sequence Analysis for Exon Prediction Using Adaptive Signal Processing AlgorithmsZia-ur Rahman, Srinivasareddy Putluri · 2021- 📕Complementable spliceosomes and the role of exon sequences in pre-mRNA splicingAnnette Suzanne Parent · 1989
- 📕Expression and regulation of the Thy-1 gene in PC12 cellsMagdi Maged Sobeih · 1993
- 📕How big is the universe of exons?Robert L. Dorit · 1989
- 📕The Terrae Occupatae of Cornwall and the Exon Domesday.Robert S. Hoyt · 1953
- 📕Alternative pre-mRNA splicing of α-tropomyosinMary Patricia Mullen · 1991
- 📕Remodeling the spliceosome for exon ligationKatrin Faye Chua · 1999
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
đź”— Related topics
- Intron An intron is any nucleotide sequence within a gene that is not expressed or operative in the final RNA product. The word intron is derived from the term…
- RNA splicing RNA splicing is a process in molecular biology where a newly-made precursor messenger RNA (pre-mRNA) transcript is transformed into a mature messenger…
- Coding region The coding region of a gene, also known as the coding DNA sequence (CDS), is the portion of a gene's DNA or RNA that codes for a protein. Studying the…
- Non-coding DNA Non-coding DNA (ncDNA) sequences are components of an organism's DNA that do not encode protein sequences. Some non-coding DNA is transcribed into functional…
- Untranslated region In molecular genetics, an untranslated region (or UTR) refers to either of two sections, one on each side of a coding sequence on a strand of mRNA. If…
- Split gene theory The split gene theory offers an explanation for the origin of eukaryotic introns. It suggests that random primordial DNA sequences would only permit short…
- Alternative splicing Alternative splicing, alternative RNA splicing, or differential splicing is an alternative splicing process during gene expression that allows a single…
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