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Everything about Intron
Part of a gene that is spliced away
An intron is any nucleotide sequence within a gene that is not expressed or operative in the final RNA product. The word intron is derived from the term intragenic region, i.e., a region inside a gene. The term intron refers to both the DNA sequence within a gene and the corresponding RNA sequence in RNA transcripts. The non-intron sequences that become joined by this RNA processing to form the mature RNA are called exons. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: IntronA 5-minute orientation
- Skim a recent paper: Author Correction: Visualizing group II intron dynamics between the first and second steps of splicingInfluential work since 2022
- Pick up a classic book: Exons, introns, and talking genesThe most-reprinted book on the subject
- Read the landmark paper: Exon-intron circular RNAs regulate transcription in the nucleusCited 2,579 times
- Go sideways: RNA splicingA closely related topic
- Go sideways: Split gene theoryA closely related topic
📖 Definitions
Noun A portion of a split gene that is included in pre-RNA transcripts but is removed during RNA processing and rapidly degraded.
🏆 Landmark papers (most cited)
Exon-intron circular RNAs regulate transcription in the nucleus
Gene prediction with a hidden Markov model and a new intron submodel
The Comparative RNA Web (CRW) Site: an online database of comparative sequence and structure information for ribosomal, intron, and other RNAs
Power and limitations of the chloroplast trnL (UAA) intron for plant DNA barcoding
Myotonic Dystrophy Type 2 Caused by a CCTG Expansion in Intron 1 of ZNF9
The U6 snRNA m 6 A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention
A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance
Removal of a cryptic intron and subcellular localization of green fluorescent protein are required to mark transgenic Arabidopsis plants brightly
🆕 Influential since 2022
Author Correction: Visualizing group II intron dynamics between the first and second steps of splicing
Histone H3K9 Lactylation Confers Temozolomide Resistance in Glioblastoma via LUC7L2‐Mediated MLH1 Intron Retention
Exon-intron boundary inhibits m6A deposition, enabling m6A distribution hallmark, longer mRNA half-life and flexible protein coding
Efficient circular RNA engineering by end-to-end self-targeting and splicing reaction using Tetrahymena group I intron ribozyme
Improved detection of aberrant splicing with FRASER 2.0 and the intron Jaccard index
📚 Books worth reading
Exons, introns, and talking genesChristopher Wills · 1991
Noncoding RNAsJan Barciszewski · 2003- 📕Evolutionary inferences from the pattern of intron conservationScott William Roy · 2005
- 📕An in vitro genetic analysis of the group I self-splicing intronRachel Green · 1992
- 📕The guanosine binding site of the Tetrahymena ribozymeMaya Hanna · 1991
- 📕Ribosomal RNA and group I intronsRachel Green · 1996
- 📕An intronic 10 base pair deletion in a class II Ab gene affects RNA processingZoher Ghogawala, Harvard Medical School · 1991
- 📕Evolution of the Peperomia coxi gene intronKeith Lee Adams · 1996
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- RNA splicing RNA splicing is a process in molecular biology where a newly-made precursor messenger RNA (pre-mRNA) transcript is transformed into a mature messenger…
- Split gene theory The split gene theory offers an explanation for the origin of eukaryotic introns. It suggests that random primordial DNA sequences would only permit short…
- Periannan Senapathy Periannan Senapathy is a molecular biologist, geneticist, author and entrepreneur. He is the founder and president of Genome International Corporation…
- Exon shuffling Exon shuffling is a molecular mechanism for the formation of new genes. It is a process through which two or more exons from different genes can be brought…
- Minor spliceosome The minor spliceosome is a complex of RNA and proteins (ribonucleoprotein complex) that catalyses the removal (splicing) of an atypical class of introns…
- Group II intron Group II introns are a large class of self-catalytic ribozymes and mobile genetic elements found within the genes of all three domains of life. Ribozyme…
- Spliceosome A spliceosome is a large complex of proteins and RNA (ribonucleoprotein) that functions to remove introns from pre-mRNA, a process called RNA splicing…
- Alternative splicing Alternative splicing, alternative RNA splicing, or differential splicing is an alternative splicing process during gene expression that allows a single…