Everything about Enhancer RNA
Type of non-coding RNA molecule
Enhancer RNAs (eRNAs) represent a class of relatively long non-coding RNA molecules transcribed from the DNA sequence of enhancer regions. They were first detected in 2010 through the use of genome-wide techniques such as RNA-seq and ChIP-seq. eRNAs can be subdivided into two main classes: 1D eRNAs and 2D eRNAs, which differ primarily in terms of their size, polyadenylation state, and transcriptional directionality. The expression of a given eRNA correlates with the activity of its corresponding enhancer in target genes. Increasing evidence suggests that eRNAs actively play a role in transcriptional regulation in cis and in trans, and while their mechanisms of action remain unclear, a few models have been proposed. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: Enhancer RNAA 5-minute orientation
- Skim a recent paper: Engineering circular RNA for enhanced protein productionInfluential work since 2022
- Pick up a classic book: Cell-penetrating peptidesThe most-reprinted book on the subject
- Read the landmark paper: RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer ActivityCited 466 times
- Go sideways: Eukaryotic transcriptionA closely related topic
- Go sideways: Promoter (genetics)A closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🏆 Landmark papers (most cited)
RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity
Enhancer RNA Facilitates NELF Release from Immediate Early Genes
HIV TAR: An RNA enhancer?
RNA polymerase II dynamics shape enhancer–promoter interactions
A High-Resolution Map of Human Enhancer RNA Loci Characterizes Super-enhancer Activities in Cancer
Enhancer RNA profiling predicts transcription factor activity
Enhancer RNA: biogenesis, function, and regulation
Enhancer RNA: What we know and what we can achieve
🆕 Influential since 2022
Engineering circular RNA for enhanced protein production
Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing
A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer
A common transcriptional mechanism involving R-loop and RNA abasic site regulates an enhancer RNA of APOE
Enhancer transcription profiling reveals an enhancer RNA-driven ferroptosis and new therapeutic opportunities in prostate cancer
📚 Books worth reading
Cell-penetrating peptidesÜlo Langel · 1985
Plant stress toleranceRamanjulu Sunkar · 2010
Essential GenesBenjamin Lewin · 2005- 📕Brain developmentSimon G. Sprecher · 2013
- 📕Flower developmentJosé Luis Riechmann, Frank Wellmer · 2014
Mouse models for drug discoveryGabriele Proetzel · 2010
Drug delivery in oncologyFelix Kratz, Peter Senter · 2012
Annual Review of MicrobiologySusan Gottesman · 2009
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Eukaryotic transcription Eukaryotic transcription is the elaborate process that eukaryotic cells use to copy genetic information stored in DNA into units of transportable complementary…
- Promoter (genetics) In genetics, a promoter is a sequence of DNA to which proteins bind to initiate transcription of a single RNA transcript from the DNA downstream of the…
- Transcriptional regulation In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby…
- RNA polymerase II RNA polymerase II (RNAP II and Pol II) is a multiprotein complex that transcribes DNA into precursors of messenger RNA (mRNA) and most small nuclear RNA…
- RNA polymerase II holoenzyme RNA polymerase II holoenzyme is a form of eukaryotic RNA polymerase II that is recruited to the promoters of protein-coding genes in living cells. It consists…
- Negative elongation factor In molecular biology, the NELF (negative elongation factor) is a four-subunit protein complex (NELF-A, NELF-B, NELF-C/NELF-D, and NELF-E) that negatively…
- STARR-seq STARR-seq (short for self-transcribing active regulatory region sequencing) is a method to assay enhancer activity for millions of candidates from arbitrary…
- Long non-coding RNA Long non-coding RNAs (long ncRNAs, lncRNA) are a type of RNA, generally defined as transcripts of more than 200 nucleotides that are not translated into…