Everything about Codeine
Opiate and prodrug of morphine used to treat pain
Codeine is an opiate and prodrug of morphine mainly used to treat pain, coughing, and diarrhea. It is commonly used as a recreational drug. It is found naturally in the sap of the opium poppy, Papaver somniferum. It is typically used to treat mild to moderate degrees of pain. Greater benefit may occur when combined with paracetamol (acetaminophen) as codeine/paracetamol or a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin or ibuprofen. Evidence does not support its use for acute cough suppression in children. In Europe, it is not recommended as a cough medicine for those under 12 years of age. It is generally taken orally. It usually starts working after half an hour, with maximum effect at two hours. Its effects last for about four to six hours. Codeine exhibits abuse potential similar to other opioid medications, including a risk of addiction and overdose. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: CodeineA 5-minute orientation
- Skim a recent paper: Codeine-associated pediatric deaths despite using recommended dosing guidelines: Three case reportsInfluential work since 2022
- Pick up a classic book: Acetaminophen-codeineThe most-reprinted book on the subject
- Read the landmark paper: Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450 2D6 Genotype and Codeine Therapy: 2014 UpdateCited 593 times
- Go sideways: DihydrocodeineA closely related topic
- Go sideways: OpiateA closely related topic
📖 Definitions
Noun An addictive alkaloid narcotic derived from opium and used as a hypnotic, analgesic and antitussive; often mixed with aspirin etc.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450 2D6 Genotype and Codeine Therapy: 2014 Update
Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism
Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother
Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication
More Codeine Fatalities After Tonsillectomy in North American Children
Codeine, Ultrarapid-Metabolism Genotype, and Postoperative Death
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Codeine Therapy in the Context of Cytochrome P450 2D6 (CYP2D6) Genotype
Blood-Brain Barrier: Penetration of Morphine, Codeine, Heroin, and Methadone after Carotid Injection
🆕 Influential since 2022
Codeine-associated pediatric deaths despite using recommended dosing guidelines: Three case reports
Fabrication of molecularly imprinted electrochemical sensors for sensitive codeine detection
Effectiveness and Safety of Codeine and Levodropropizine in Patients With Chronic Cough
L-Arginine reverses maternal and pre-pubertal codeine exposure-induced sexual dysfunction via upregulation of androgen receptor gene and NO/cGMP signaling
Sales of Over-the-Counter Products Containing Codeine in 31 Countries, 2013–2019: A Retrospective Observational Study
📚 Books worth reading
- 📕Acetaminophen-codeineJudy Folkenberg · 1991
Codeine - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet ReferencesICON Health Publications · 2003
CodeineBrigid M. Kane · 2007- 📕Morphine-codeine interactions in rodentsJerome W. Blank · 1970
Codeine (Drugs: the Straight Facts)Brigid M. Kane · 2006- 📕Morphine and codeineTorkell Jóhannesson · 1967
Coca and cocaineMartindale, William · 1892- 📕Report [on] codeine and its salts (Dumping and subsidies act) 19 February 1969Australia. Tariff Board. · 1969
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Dihydrocodeine Dihydrocodeine, sold under the brand name Dicodin among others, is a semi-synthetic opioid analgesic prescribed for pain or severe dyspnea, or as an antitussive…
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- Hydrocodone Hydrocodone, also known as dihydrocodeinone, is a semi-synthetic opioid used to treat pain and as a cough suppressant. It is taken by mouth. Typically…
- Opioid Opioids are a class of drugs that derive from, or mimic, natural substances found in the opium poppy plant. Opioids work on opioid receptors in the brain…
- Morphine Morphine, formerly known as morphium, is an opiate found naturally in opium, a dark brown resin produced by drying the latex of opium poppies (Papaver…
- Codeine/paracetamol Codeine/paracetamol, also called codeine/acetaminophen and co-codamol, is a compound analgesic, comprising codeine phosphate and paracetamol (acetaminophen)…
- Paregoric Paregoric, or camphorated tincture of opium, also known as tinctura opii camphorata, is a patent medicine known for its antidiarrheal, antitussive, and…
- Laudanum Laudanum is a tincture of opium containing approximately 10% powdered opium by weight (the equivalent of 1% morphine). Laudanum is prepared by dissolving…