Everything about Dihydrocodeine

🧭 Start here: a 6-step reading path

1. Read the overview: DihydrocodeineA 5-minute orientation
2. Skim a recent paper: Highlighting the hidden dangers of a ‘weak’ opioid: Deaths following use of dihydrocodeine in England (2001–2020)Influential work since 2022
3. Pick up a classic book: Traffic in opium and other dangerous drugsThe most-reprinted book on the subject
4. Read the landmark paper: Effects of Dihydrocodeine, Alcohol, and Caffeine on Breathlessness and Exercise Tolerance in Patients with Chronic Obstructive Lung Disease and Normal Blood GasesCited 195 times
5. Go sideways: CodeineA closely related topic
6. Go sideways: HydrocodoneA closely related topic

🏆 Landmark papers (most cited)

• Effects of Dihydrocodeine, Alcohol, and Caffeine on Breathlessness and Exercise Tolerance in Patients with Chronic Obstructive Lung Disease and Normal Blood Gases

  Ashley A. Woodcock, Elizabeth R. Gross, Andrew Gellert · 1981 · New England Journal of Medicine · 195 citations

• Affinity profiles of morphine, codeine, dihydrocodeine and their glucuronides at opioid receptor subtypes

  Christian Mignat, Uta Wille, Albrecht Ziegler · 1995 · Life Sciences · 154 citations

• Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study

  B Frank, M G Serpell, J Hughes · 2008 · BMJ · 149 citations

• Effects of Dihydrocodeine on Chemosensitivity and Exercise Tolerance in Patients With Chronic Heart Failure

  Tuan Peng Chua, Derek Harrington, Piotr Ponikowski · 1997 · Journal of the American College of Cardiology · 125 citations

• Dihydrocodeine for breathlessness in "pink puffers".

  M A Johnson, A A Woodcock, D M Geddes · 1983 · BMJ · 92 citations

• Treatment of severe pain from osteoarthritis with slow-release tramadol or dihydrocodeine in combination with NSAID's: a randomised study comparing analgesia, antinociception and gastrointestinal effects

  C. H. Wilder-Smith, L. Hill, K. Spargo · 2001 · Pain · 74 citations

• Efficacy and safety of levodropropizine and dihydrocodeine on nonproductive cough in primary and metastatic lung cancer

  G Luporini, S Barni, E Marchi · 1998 · European Respiratory Journal · 62 citations

• Enantioselective Synthesis of (−)-Dihydrocodeine and Formal Synthesis of (−)-Thebaine, (−)-Codeine, and (−)-Morphine from a Deprotonated α-Aminonitrile

  Mario Geffe, Till Opatz · 2014 · Organic Letters · 49 citations

🆕 Influential since 2022

• Highlighting the hidden dangers of a ‘weak’ opioid: Deaths following use of dihydrocodeine in England (2001–2020)

  Kirsten L. Rock, Laura M. Reynolds, Paul Rees · 2022 · Drug and Alcohol Dependence · 10 citations

• Is dihydrocodeine the ideal opioid for use after discharge from hospital?

  Nicholas Levy · 2022 · British Journal of Pain · 2 citations

• Development of a Sensitive and Rapid HPLC–MS Method for Dihydrocodeine and Dihydromorphine: Application to Bioequivalence Studies

  Zhenyu Zhu, Xiaomei Huang, Zheng Tan · 2022 · Journal of Chromatographic Science · 1 citations

• Management of opiate dependence related to dihydrocodeine–sorbitol misuse

  Richard CJ Bradlow, Baden Hicks, Temika Mu · 2023 · Medical Journal of Australia · 1 citations

• Probable neuropsychiatric toxicity induced by dihydrocodeine in a peritoneal dialysis patient: a case report and literature review

  Zihan Lei, Jiaqi Xu, Yunfang Zhang · 2026 · BMC Nephrology · 0 citations

📚 Books worth reading

• 📕Traffic in opium and other dangerous drugsLeague of Nations. Advisory Committee on Traffic in Opium and Other Dangerous Drugs. · 1939

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics

• Codeine Codeine is an opiate and prodrug of morphine mainly used to treat pain, coughing, and diarrhea. It is commonly used as a recreational drug. It is found…
• Hydrocodone Hydrocodone, also known as dihydrocodeinone, is a semi-synthetic opioid used to treat pain and as a cough suppressant. It is taken by mouth. Typically…
• Co-dydramol Co-dydramol (BAN) is a non-proprietary name used to denote a particular compound analgesic, a combination of dihydrocodeine tartrate and paracetamol. Co-dydramo…
• Dihydromorphine Dihydromorphine (Paramorfan, Paramorphan) is a semi-synthetic opioid structurally related to and derived from morphine. The 7,8-double bond in morphine…
• Phenyltoloxamine Phenyltoloxamine is an antihistamine with sedative and analgesic effects. It is available in combination with other drugs such as paracetamol (acetominophen)…
• Thebacon Thebacon (INN; pronounced /ˈθiːbəkɒn/), or dihydrocodeinone enol acetate, is a semisynthetic opioid that is similar to hydrocodone and is most commonly…
• Dextropropoxyphene Dextropropoxyphene is an opioid analgesic patented in 1955 and manufactured by Eli Lilly and Company. It is an optical isomer of levopropoxyphene. It is…
• Codeine/paracetamol Codeine/paracetamol, also called codeine/acetaminophen and co-codamol, is a compound analgesic, comprising codeine phosphate and paracetamol (acetaminophen)…