Everything about CHRNB4

🧭 Start here: a 6-step reading path

1. Read the overview: CHRNB4A 5-minute orientation
2. Skim a recent paper: Investigating CHRNA5, CHRNA3, and CHRNB4 variants in the genetic landscape of substance use disorder in JordanInfluential work since 2022
3. Read the landmark paper: The CHRNA5-CHRNA3-CHRNB4 Nicotinic Receptor Subunit Gene Cluster Affects Risk for Nicotine Dependence in African-Americans and in European-AmericansCited 233 times
4. Go sideways: CHRNA3A closely related topic
5. Go sideways: CHRNA2A closely related topic

🏆 Landmark papers (most cited)

• The CHRNA5-CHRNA3-CHRNB4 Nicotinic Receptor Subunit Gene Cluster Affects Risk for Nicotine Dependence in African-Americans and in European-Americans

  Nancy L. Saccone, Jen C. Wang, Naomi Breslau · 2009 · Cancer Research · 233 citations

• Relationship Between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 Variation and Smoking Behaviors and Lung Cancer Risk

  Catherine A. Wassenaar, Qiong Dong, Qingyi Wei · 2011 · JNCI: Journal of the National Cancer Institute · 160 citations

• Interplay of Genetic Risk Factors ( CHRNA5 - CHRNA3 - CHRNB4 ) and Cessation Treatments in Smoking Cessation Success

  Li-Shiun Chen, Timothy B. Baker, Megan E. Piper · 2012 · American Journal of Psychiatry · 131 citations

• A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5–CHRNA3–CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy

  Rachel M. Freathy, Susan M. Ring, Beverley Shields · 2009 · Human Molecular Genetics · 130 citations

• Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15

  Kaisu Keskitalo, Ulla Broms, Markku Heliövaara · 2009 · Human Molecular Genetics · 106 citations

• Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index

  R. M. Freathy, G. R. Kazeem, R. W. Morris · 2011 · International Journal of Epidemiology · 101 citations

• Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5–CHRNA3–CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight

  Jessica Tyrrell, Ville Huikari, Jennifer T. Christie · 2012 · Human Molecular Genetics · 72 citations

• Cone Genesis Tracing by the Chrnb4-EGFP Mouse Line: Evidences of Cellular Material Fusion after Cone Precursor Transplantation

  Sarah Decembrini, Catherine Martin, Florian Sennlaub · 2017 · Molecular Therapy · 67 citations

🆕 Influential since 2022

• Investigating CHRNA5, CHRNA3, and CHRNB4 variants in the genetic landscape of substance use disorder in Jordan

  Laith AL-Eitan, Mohammad Shatnawi, Mansour Alghamdi · 2024 · BMC Psychiatry · 6 citations

• CHRNB4-Mediated Neuroactive Signaling Rewiring Drives Adaptive Resistance to BCL-2 Inhibition in Acute Myeloid Leukemia

  Hiroaki Koyama, Sachiko Seo, William Tse · 2026 · Cancers · 2 citations

• The impact of bilberry extract combined with docosahexaenoic acid on the expression of Chrnb4 gene in the sclera of myopic guinea pigs

  Mei-hong Zhu, Qian Wen, Tai-nan Lin · 2025 · Frontiers in Medicine · 2 citations

• Tetra‐primer amplification refractory mutation system (ARMS) PCR used to detect 3’UTR rs1948 mutation in CHRNB4

  Anggi Laksmita Dewi, Dewi Kartikawati Paramita, Jajah Fachiroh · 2022 · Indonesian Journal of Biotechnology · 1 citations

• Hubungan Polimorfisme Genetik Nicotinic Acelycholine Recepttor CHRNB4 dengan Hasil VEP1 dan KVP pada Pasien Penyakit Paru Obstriktif Kronik

  Muhammad Haekal Hakim, Setia Putra Tarigan, Amira Permatasari Tarigan · 2026 · Jurnal Pengabdian Ilmu Kesehatan · 0 citations

📚 Books worth reading

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🔗 Related topics

• CHRNA3 Neuronal acetylcholine receptor subunit alpha-3, also known as nAChRα3, is a protein that in humans is encoded by the CHRNA3 gene. The protein encoded…
• CHRNA2 Neuronal acetylcholine receptor subunit alpha-2, also known as nAChRα2, is a protein that in humans is encoded by the CHRNA2 gene. The protein encoded…
• CHRNB3 Neuronal acetylcholine receptor subunit beta-3 is a protein that in humans is encoded by the CHRNB3 gene. This gene has been identified as a candidate…
• CHRNB2 Neuronal acetylcholine receptor subunit beta-2 is a protein that in humans is encoded by the CHRNB2 gene. Neuronal acetylcholine receptors are homo- or…
• CHRNA7 Neuronal acetylcholine receptor subunit alpha-7, also known as nAChRα7, is a protein that in humans is encoded by the CHRNA7 gene. The protein encoded…
• CHRNA4 Neuronal acetylcholine receptor subunit alpha-4, also known as nAChRα4, is a protein that in humans is encoded by the CHRNA4 gene. The protein encoded…
• CHRNA6 Cholinergic receptor, nicotinic, alpha 6, also known as nAChRα6, is a protein that in humans is encoded by the CHRNA6 gene. The CHRNA6 gene codes for the…
• CHRNA9 Neuronal acetylcholine receptor subunit alpha-9, also known as nAChRα9, is a protein that in humans is encoded by the CHRNA9 gene. The protein encoded…