Everything about Nicotinic acetylcholine receptor
Acetylcholine receptors named for their selective binding of nicotine
Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the central and peripheral nervous system, muscle, and many other tissues of many organisms. At the neuromuscular junction they are the primary receptor in muscle for motor nerve-muscle communication that controls muscle contraction. In the peripheral nervous system: (1) they transmit outgoing signals from the presynaptic to the postsynaptic cells within the sympathetic and parasympathetic nervous system; and (2) they are the receptors found on skeletal muscle that receives acetylcholine released to signal for muscular contraction. In the immune system, nAChRs regulate inflammatory processes and signal through distinct intracellular pathways. In insects, the cholinergic system is limited to the central nervous system. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: Nicotinic acetylcholine receptorA 5-minute orientation
- Skim a recent paper: Rare coding variants in CHRNB3 associate with reduced daily cigarette smoking across ancestriesInfluential work since 2022
- Read the landmark paper: Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behaviorCited 605 times
- Go sideways: Nicotinic agonistA closely related topic
- Go sideways: Acetylcholine receptorA closely related topic
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🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior
Genetic Association of the CHRNA6 and CHRNB3 Genes with Tobacco Dependence in a Nationally Representative Sample
The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco
SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample
Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence
Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans
Crucial roles of the CHRNB3–CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research
Significant association of CHRNB3 variants with nicotine dependence in multiple ethnic populations
🆕 Influential since 2022
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🔗 Related topics
- Nicotinic agonist A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). The nAChR is named for its affinity…
- Acetylcholine receptor An acetylcholine receptor (abbreviated AChR) or a cholinergic receptor is an integral membrane protein that responds to the binding of acetylcholine, a…
- Alpha-4 beta-2 nicotinic receptor The alpha-4 beta-2 nicotinic receptor, also known as the α4β2 receptor, is a type of nicotinic acetylcholine receptor implicated in learning, consisting…
- Alpha-7 nicotinic receptor The alpha-7 nicotinic receptor, also known as the α7 receptor, is a type of nicotinic acetylcholine receptor implicated in long-term memory, consisting…
- Alpha-3 beta-4 nicotinic receptor The alpha-3 beta-4 nicotinic receptor, also known as the α3β4 receptor and the ganglion-type nicotinic receptor, is a type of nicotinic acetylcholine receptor…
- Α-Bungarotoxin α-Bungarotoxin is one of the bungarotoxins, components of the venom of the elapid Taiwanese banded krait snake (Bungarus multicinctus). It is a type of…
- CHRNA6 Cholinergic receptor, nicotinic, alpha 6, also known as nAChRα6, is a protein that in humans is encoded by the CHRNA6 gene. The CHRNA6 gene codes for the…
- CHRNA5 Neuronal acetylcholine receptor subunit alpha-5 (or α5 nAChR) is a protein that in humans is encoded by the CHRNA5 gene. This protein is a type of ligand…