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Everything about UK Biobank
Long-term biobank study of 500,000 people
UK Biobank is a long-term prospective biobank study in the United Kingdom (UK) that houses the de-identified biological samples and health-related data of half a million people. The volunteer participants aged 40–69 were recruited between 2006 and 2010 from across Great Britain and consented both to share their health data and to be followed for at least 30 years thereafter, with the aim to enable scientific discoveries into the prevention, diagnosis, and treatment of disease. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: UK BiobankA 5-minute orientation
- Skim a recent paper: SARS-CoV-2 is associated with changes in brain structure in UK BiobankInfluential work since 2022
- Pick up a classic book: Principles and practice in biobank governanceThe most-reprinted book on the subject
- Read the landmark paper: UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old AgeCited 13,206 times
- Go sideways: Health effects of coffeeA closely related topic
- Go sideways: Naomi Allen (scientist)A closely related topic
📖 Definitions
Noun Any of several types of repository of biological material (e.g. seeds) or information (e.g. DNA).
Verb To store (biological material) in a biobank.
🏆 Landmark papers (most cited)
UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
The UK Biobank resource with deep phenotyping and genomic data
Comparison of Sociodemographic and Health-Related Characteristics of UK Biobank Participants With Those of the General Population
Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients
Multimodal population brain imaging in the UK Biobank prospective epidemiological study
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity
Plasma proteomic associations with genetics and health in the UK Biobank
Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank
🆕 Influential since 2022
SARS-CoV-2 is associated with changes in brain structure in UK Biobank
Atlas of plasma NMR biomarkers for health and disease in 118,461 individuals from the UK Biobank
The sequences of 150,119 genomes in the UK Biobank
Participation bias in the UK Biobank distorts genetic associations and downstream analyses
Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort
📚 Books worth reading
- 📕Principles and practice in biobank governanceJane Kaye, Mark Stranger · 2009
Methods in biobankingJoakim Dillner · 2011
BiobanksHerbe Gottweis · 2008
Biobanking and Cryopreservation of Stem CellsFeridoun Karimi-Busheri, Michael Weinfeld · 2016
Biobanking in the 21st CenturyFeridoun Karimi-Busheri · 2015- 📕BiobanksAntonella De Robbio · 2012
Biobanks and tissue researchChristian Lenk, Judit Sándor · 2011
The ethics of research biobankingJan Helge Solbakk · 2009
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
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