Everything about U3

🧭 Start here: a 6-step reading path

1. Read the overview: U3A 5-minute orientation
2. Skim a recent paper: U3 snoRNA‐mediated degradation of ZBTB7A regulates aerobic glycolysis in isocitrate dehydrogenase 1 wild‐type glioblastoma cellsInfluential work since 2022
3. Pick up a classic book: The Ugly AmericanThe most-reprinted book on the subject
4. Read the landmark paper: A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesisCited 628 times
5. Go sideways: U2 (disambiguation)A closely related topic
6. Go sideways: U1A closely related topic

🏆 Landmark papers (most cited)

• A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis

  François Dragon, Jennifer E. G. Gallagher, Patricia A. Compagnone-Post · 2002 · Nature · 628 citations

• 90S Pre-Ribosomes Include the 35S Pre-rRNA, the U3 snoRNP, and 40S Subunit Processing Factors but Predominantly Lack 60S Synthesis Factors

  Paola Grandi, Vladimir Rybin, Jochen Baßler · 2002 · Molecular Cell · 406 citations

• Identification of protein binding sites on U3 snoRNA and pre-rRNA by UV cross-linking and high-throughput analysis of cDNAs

  Sander Granneman, Grzegorz Kudla, Elisabeth Petfalski · 2009 · Proceedings of the National Academy of Sciences · 390 citations

• The U3 small nucleolar ribonucleoprotein functions in the first step of preribosomal RNA processing

  Susan Kass, Kazimierz Tyc, Joan A. Steitz · 1990 · Cell · 340 citations

• U3, U8 and U13 comprise a new class of mammalian snRNPs localized in the cell nucleolus.

  K. Tyc, J.A. Steitz · 1989 · The EMBO Journal · 288 citations

• Depletion of U3 small nucleolar RNA inhibits cleavage in the 5′ external transcribed spacer of yeast pre‐ribosomal RNA and impairs formation of 18S ribosomal RNA.

  J.M. Hughes, M. Ares · 1991 · The EMBO Journal · 260 citations

• RNase III Cleaves Eukaryotic Preribosomal RNA at a U3 snoRNP-Dependent Site

  Sherif Abou Elela, Haller Igel, Manuel Ares · 1996 · Cell · 203 citations

• Identification and functional analysis of two U3 binding sites on yeast pre‐ribosomal RNA.

  M. Beltrame, D. Tollervey · 1992 · The EMBO Journal · 197 citations

🆕 Influential since 2022

• U3 snoRNA‐mediated degradation of ZBTB7A regulates aerobic glycolysis in isocitrate dehydrogenase 1 wild‐type glioblastoma cells

  Weiwei Dong, Yunhui Liu, Ping Wang · 2023 · CNS Neuroscience & Therapeutics · 16 citations

• In vitro structural maturation of an early stage pre-40S particle coupled with U3 snoRNA release and central pseudoknot formation

  Jingdong Cheng, Giuseppe La Venuta, Benjamin Lau · 2022 · Nucleic Acids Research · 14 citations

• DEAD-box RNA helicase 10 is required for 18S rRNA maturation by controlling the release of U3 snoRNA from pre-rRNA in embryonic stem cells

  Xiuqin Wang, Gongcheng Hu, Lisha Wang · 2024 · Nature Communications · 11 citations

• U3-YOLOXs: An improved YOLOXs for Uncommon Unregular Unbalance detection of the rape subhealth regions

  Xinjing Gong, Xihai Zhang, Ruwen Zhang · 2022 · Computers and Electronics in Agriculture · 10 citations

• Phase 1 study of patritumab deruxtecan (HER3-DXd; U3-1402) in combination with osimertinib in patients with advanced EGFR-mutated NSCLC.

  Pasi A. Janne, Joseph Mostillo, Pomy Shrestha · 2022 · Journal of Clinical Oncology · 9 citations

📚 Books worth reading

• The Ugly AmericanWilliam J. Lederer, Eugene Burdick · 1958
• UbikPhilip K. Dick · 1969
• Hillbilly ElegyJ. D. Vance · 2016
• Black Elk speaksBlack Elk, John Gneisenau Neihardt · 1932
• It's a dog's lifeJohn R. Erickson · 1984
• The ways of white folksLangston Hughes · 1934
• Wild Bill HickokLarissa Phillips, Tracie Egan · 2003
• Understanding health policyThomas Bodenheimer, Thomas S. Bodenheimer · 1995

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

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