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Everything about Transposable element

DNA sequence that jumps/transposes within a genome

Transposable elements (TEs), also known as transposons, jumping genes, or mobile genetic elements, are DNA sequences that can change their position, or translocate, within a genome. TEs were first identified via genetic studies in maize by Barbara McClintock, a discovery for which she was awarded the 1983 Nobel Prize in Physiology or Medicine. TEs are found in most species across all branches of the tree of life. Currently there are two classifications of TEs: Class I and Class II TEs. Class I TEs or retrotransposons, generally function via utilization of reverse transcription to "copy and paste" themselves into a different area of the genome. Class II TEs or DNA transposons, encode for the protein transposase, which they require for insertion, excision, or other TE functions. Wikipedia →

🧭 Start here: a 6-step reading path

  1. Read the overview: Transposable elementA 5-minute orientation
  2. Skim a recent paper: Roles of transposable elements in the regulation of mammalian transcriptionInfluential work since 2022
  3. Pick up a classic book: Survival of the SickestThe most-reprinted book on the subject
  4. Read the landmark paper: RepeatModeler2 for automated genomic discovery of transposable element familiesCited 4,256 times
  5. Go sideways: RetrotransposonA closely related topic
  6. Go sideways: LINE1A closely related topic

📖 Definitions

Noun Synonym of transposon.

🗂️ The subject at a glance

  1. Discovery
  2. Classification
  3. Genomic locations
  4. Diseases and other negative effects
  5. Evolution
  6. Transposition rates and defense
  7. Miscellaneous topics

🏆 Landmark papers (most cited)

🆕 Influential since 2022

📚 Books worth reading

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics