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Everything about SnRNP
Protein complexes that mix with other proteins to form spliceosome
snRNPs, or small nuclear ribonucleoproteins, are RNA-protein complexes that combine with unmodified pre-mRNA and various other proteins to form a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs. The action of snRNPs is essential to the removal of introns from pre-mRNA, a critical aspect of post-transcriptional modification of RNA, occurring only in the nucleus of eukaryotic cells. Additionally, U7 snRNP is not involved in splicing at all, as U7 snRNP is responsible for processing the 3′ stem-loop of histone pre-mRNA. Wikipedia →
🧠Start here: a 6-step reading path
- Read the overview: SnRNPA 5-minute orientation
- Skim a recent paper: U1 snRNP increases RNA Pol II elongation rate to enable synthesis of long genesInfluential work since 2022
- Pick up a classic book: Assembly of functional U1 and U2 snRNPs in Xenopus laevis oocytesThe most-reprinted book on the subject
- Read the landmark paper: U1 snRNP regulates cancer cell migration and invasion in vitroCited 6,494 times
- Go sideways: Small nuclear RNAA closely related topic
- Go sideways: Minor spliceosomeA closely related topic
đź“– Definitions
No dictionary entry for this exact phrase.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
U1 snRNP regulates cancer cell migration and invasion in vitro
U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation
The Spinal Muscular Atrophy Disease Gene Product, SMN, and Its Associated Protein SIP1 Are in a Complex with Spliceosomal snRNP Proteins
The SMN–SIP1 Complex Has an Essential Role in Spliceosomal snRNP Biogenesis
Essential Role for the SMN Complex in the Specificity of snRNP Assembly
U1 snRNP Determines mRNA Length and Regulates Isoform Expression
A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein
Promoter directionality is controlled by U1 snRNP and polyadenylation signals
🆕 Influential since 2022
U1 snRNP increases RNA Pol II elongation rate to enable synthesis of long genes
Alzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment
Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly
Sequence-specific RNA recognition by an RGG motif connects U1 and U2 snRNP for spliceosome assembly
The splicing regulators RBM5 and RBM10 are subunits of the U2 snRNP engaged with intron branch sites on chromatin
đź“š Books worth reading
- 📕Assembly of functional U1 and U2 snRNPs in Xenopus laevis oocytesZhenqiang Pan · 1989
- 📕Xenopus laevis U snRNPsRolf Zeller · 1984
- 📕Immunologische und molekularbiologische Charakterisierung eines autoreaktiven U-snRNP spezifischen humanen T-ZellklonsGuido Wolff-Vorbeck · 1993
- 📕Trans-Splicing in Trypanosoma bruceiArthur Günzl · 1992
- 📕Protein-protein-interaktionen der U1snRNP-Komponente Prp40 und deren FF-Domanen in Saccharomyces cerevisiaeClaudia Ester · 2007
- 📕RNA-Protein-Wechselwirkungen in kleinen RNA-Proteinkomplexen des Zellkerns (UsnRNPs) und post-translationale Modifikationen der snRNP-ProteineAndreas Woppmann · 1989
- 📕Charakterisierung des U7-snRNP, einer essentiellen komponente bei der bildung von korrekten 3'-enden der histon-mRNAKatharina Strub · 1986
Spliceosomal pre-mRNA splicingKlemens J. Hertel · 2014
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
đź”— Related topics
- Small nuclear RNA Small nuclear RNA (snRNA) is a class of small RNA molecules that are found within the splicing speckles and Cajal bodies of the cell nucleus in eukaryotic…
- Minor spliceosome The minor spliceosome is a complex of RNA and proteins (ribonucleoprotein complex) that catalyses the removal (splicing) of an atypical class of introns…
- U11 spliceosomal RNA The U11 snRNA (small nuclear ribonucleic acid) is an important non-coding RNA in the minor spliceosome protein complex, which activates the alternative…
- U4 spliceosomal RNA The U4 small nuclear Ribo-Nucleic Acid (U4 snRNA) is a non-coding RNA component of the major or U2-dependent spliceosome – a eukaryotic molecular machine…
- Spliceosome A spliceosome is a large complex of proteins and RNA (ribonucleoprotein) that functions to remove introns from pre-mRNA, a process called RNA splicing…
- LSm In molecular biology, LSm proteins are a family of RNA-binding proteins found in virtually every cellular organism. LSm is a contraction of 'like Sm',…
- Kiyoshi Nagai Kiyoshi Nagai FRS (June 25, 1949 – September 27, 2019) was a Japanese structural biologist at the MRC Laboratory of Molecular Biology Cambridge, UK. He…
- U1 spliceosomal RNA U1 spliceosomal RNA is the small nuclear RNA (snRNA) component of U1 snRNP (small nuclear ribonucleoprotein), an RNA-protein complex that combines with…