Everything about SRP

🧭 Start here: a 6-step reading path

1. Read the overview: SRPA 5-minute orientation
2. Skim a recent paper: Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targetingInfluential work since 2022
3. Pick up a classic book: WcThe most-reprinted book on the subject
4. Read the landmark paper: Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.Cited 611 times
5. Go sideways: PSRA closely related topic
6. Go sideways: PPPA closely related topic

🏆 Landmark papers (most cited)

• Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.

  P Walter, G Blobel · 1981 · The Journal of cell biology · 611 citations

• Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein.

  P Walter, I Ibrahimi, G Blobel · 1981 · The Journal of cell biology · 512 citations

• The effect of SRP on the clinical and microbiological parameters of periodontal diseases

  A. D. Haffajee, M. A. Cugini, S. Dibart · 1997 · Journal of Clinical Periodontology · 368 citations

• Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in-vitro-assembled polysomes synthesizing secretory protein.

  P Walter, G Blobel · 1981 · The Journal of cell biology · 345 citations

• Clinical features and prognosis in anti-SRP and anti-HMGCR necrotising myopathy

  Yurika Watanabe, Akinori Uruha, Shigeaki Suzuki · 2016 · Journal of Neurology, Neurosurgery & Psychiatry · 297 citations

• The Escherichia coli SRP and SecB targeting pathways converge at the translocon

  Quido A. Valent, Pier A. Scotti, Stephen High · 1998 · The EMBO Journal · 252 citations

• Early events in preprotein recognition in E. coli: interaction of SRP and trigger factor with nascent polypeptides.

  Q. A. Valent, D. A. Kendall, S. High · 1995 · The EMBO Journal · 247 citations

• Efficient Selection of DARPins with Sub-nanomolar Affinities using SRP Phage Display

  Daniel Steiner, Patrik Forrer, Andreas Plückthun · 2008 · Journal of Molecular Biology · 246 citations

🆕 Influential since 2022

• Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting

  Ahmad Jomaa, Martin Gamerdinger, Hao-Hsuan Hsieh · 2022 · Science · 111 citations

• Delandistrogene Moxeparvovec Gene Therapy in Ambulatory Patients (Aged ≥4 to <8 Years) with Duchenne Muscular Dystrophy: 1‐Year Interim Results from Study SRP‐9001‐103 (ENDEAVOR)

  Craig M. Zaidman, Crystal M. Proud, Craig M. McDonald · 2023 · Annals of Neurology · 102 citations

• Single-cell analysis of refractory anti-SRP necrotizing myopathy treated with anti-BCMA CAR-T cell therapy

  Chuan Qin, Ming-Hao Dong, Luo-Qi Zhou · 2024 · Proceedings of the National Academy of Sciences · 93 citations

• Expression of SRP-9001 dystrophin and stabilization of motor function up to 2 years post-treatment with delandistrogene moxeparvovec gene therapy in individuals with Duchenne muscular dystrophy

  Jerry R. Mendell, Perry B. Shieh, Craig M. McDonald · 2023 · Frontiers in Cell and Developmental Biology · 89 citations

• Anti-SRP immune-mediated necrotizing myopathy: A critical review of current concepts

  Xue Ma, Bi-Tao Bu · 2022 · Frontiers in Immunology · 51 citations

📚 Books worth reading

• 📕WcVaughn Edward · 2024
• KṛṣṇaA. C. Bhaktivedanta Swami Srila Prabhupada · 1970
• 📕Developing Supervisory Review and Evaluation Process SRP FrameworkNehmat Hantas, Sebastien Clanet · 2024
• 📕An update of the total-strain version of SRPJames F. Saltsman · 1985
• 📕Rechtsradikalismus im NachkriegsdeutschlandOtto Büsch, Peter Furth · 1967
• 📕Martin KrajcKarel Srp · 2019
• 📕Electrical resistivities of glass melts containing simulated SRP waste sludgesJ. R. Wiley · 1978
• 📕SRP

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

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