Everything about SRC

🧭 Start here: a 6-step reading path

1. Read the overview: SRCA 5-minute orientation
2. Skim a recent paper: Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expressionInfluential work since 2022
3. Pick up a classic book: Abl Family Kinases in Development and DiseaseThe most-reprinted book on the subject
4. Read the landmark paper: CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASESCited 2,193 times
5. Go sideways: SBCA closely related topic
6. Go sideways: CSS (disambiguation)A closely related topic

🏆 Landmark papers (most cited)

• CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

  Sheila M. Thomas, Joan S. Brugge · 1997 · Annual Review of Cell and Developmental Biology · 2,193 citations

• Backbone Dynamics of a Free and a Phosphopeptide-Complexed Src Homology 2 Domain Studied by 15N NMR Relaxation

  Neil A. Farrow, Ranjith Muhandiram, Alex U. Singer · 1994 · Biochemistry · 1,965 citations

• Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

  Jeffrey H. Hanke, Joseph P. Gardner, Robert L. Dow · 1996 · Journal of Biological Chemistry · 1,693 citations

• Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

  Philipps Soriano, Charles Montgomery, Robert Geske · 1991 · Cell · 1,674 citations

• Integrin-regulated FAK–Src signaling in normal and cancer cells

  Satyajit K Mitra, David D Schlaepfer · 2006 · Current Opinion in Cell Biology · 1,438 citations

• β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes

  L. M. Luttrell, S. S. G. Ferguson, Y. Daaka · 1999 · Science · 1,299 citations

• Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

  L Whitesell, E G Mimnaugh, B De Costa · 1994 · Proceedings of the National Academy of Sciences · 1,242 citations

• The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

  David Vetrie, Igor Vořechovský, Paschalis Sideras · 1993 · Nature · 1,234 citations

🆕 Influential since 2022

• Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression

  Zhenzhen Pan, Kai Wang, Xiniao Wang · 2022 · Molecular Cancer · 159 citations

• Targeting Src reactivates pyroptosis to reverse chemoresistance in lung and pancreatic cancer models

  Liangping Su, Yitian Chen, Cheng Huang · 2023 · Science Translational Medicine · 129 citations

• Src: coordinating metabolism in cancer

  Sara G. Pelaz, Arantxa Tabernero · 2022 · Oncogene · 128 citations

• SRC kinase-mediated signaling pathways and targeted therapies in breast cancer

  Juan Luo, Hailin Zou, Yibo Guo · 2022 · Breast Cancer Research · 118 citations

• TGFBI secreted by tumor-associated macrophages promotes glioblastoma stem cell-driven tumor growth via integrin αvβ5-Src-Stat3 signaling

  Peng Peng, Hongtao Zhu, Dan Liu · 2022 · Theranostics · 117 citations

📚 Books worth reading

• Abl Family Kinases in Development and DiseaseAnthony Koleske · 2006
• Protein Tyrosine KinasesFrank McCormick · 2005
• 📕Generation of recombinant protein tyrosine kinase oncogenesPeter Andrew Hevezi · 1991
• 📕Above ground leafless woody biomass and nutrient content within different compartments of a P. maximowicii × P. trichocarpa poplar cloneChristopher David Morhart · 2013
• 📕The role of ubiquitination in Cbl-mediated negative regulation of the Src-family and Syk/ZAP-70 tyrosine kinasesNavin Leslie Rao · 2002
• 📕Broadband adiabatic mixing and the structure of the SH3 domain in CD2BP1 by solution NMR spectroscopyAndrew Bennett · 2003
• Src family tyrosine kinases in leukocytesTomas Mustelin · 1994
• Abl family kinases in development and disease · 2007

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics

• SBC Look up SBC in Wiktionary, the free dictionary. SBC may refer to: St Bernard's College, Lower Hutt, Wellington, New Zealand St. Brendan's College, Yeppoon…
• CSS (disambiguation) Look up CSS in Wiktionary, the free dictionary. CSS, or Cascading Style Sheets, is a language used to describe the style of document presentations in web…
• SMC SMC may refer to: St. Michael's College, Iligan City, Philippines Santa Monica College, California, US Sargodha Medical College, Punjab, Pakistan Senior…
• NSC Look up NSC in Wiktionary, the free dictionary. NSC may refer to: National Sort Code, an Irish bank code Nomura Securities Co, an investment bank National…
• ARC Look up ARC in Wiktionary, the free dictionary. ARC may refer to: ARC Magazine (Art. Recognition. Culture.), Caribbean ARChive of Contemporary Music, a…
• ABC Look up ABC, abc, or Abc in Wiktionary, the free dictionary. ABC, abc, or Abc commonly refers to: ABC, the first three letters of the Latin script ABC…
• ASC ASC may refer to: Anglican Schools Commission, Australia Andres Soriano Colleges of Bislig, located in Surigao del Sur, Philippines Agnes Scott College…
• SRC Inc. SRC Inc., formerly Syracuse Research Corporation, is an independent, not-for-profit research and development company in the defense, environment, and intelligen…