Everything about ASC

🧭 Start here: a 6-step reading path

1. Read the overview: ASCA 5-minute orientation
2. Skim a recent paper: Didymin Suppresses Microglia Pyroptosis and Neuroinflammation Through the Asc/Caspase-1/GSDMD Pathway Following Experimental Intracerebral HemorrhageInfluential work since 2022
3. Pick up a classic book: The WorksThe most-reprinted book on the subject
4. Read the landmark paper: AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASCCited 2,412 times
5. Go sideways: List of acronyms: AA closely related topic
6. Go sideways: DSCA closely related topic

🏆 Landmark papers (most cited)

• AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

  Veit Hornung, Andrea Ablasser, Marie Charrel-Dennis · 2009 · Nature · 2,412 citations

• Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

  Haitao Wen, Denis Gris, Yu Lei · 2011 · Nature Immunology · 1,698 citations

• Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

  Sanjeev Mariathasan, Kim Newton, Denise M. Monack · 2004 · Nature · 1,591 citations

• Remarks on the use of the apparent surface charges (ASC) methods in solvation problems: Iterative versus matrix‐inversion procedures and the renormalization of the apparent charges

  R. Cammi, J. Tomasi · 1995 · Journal of Computational Chemistry · 1,411 citations

• Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

  Alvin Lu, Venkat Giri Magupalli, Jianbin Ruan · 2014 · Cell · 1,334 citations

• Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

  Carmen Venegas, Sathish Kumar, Bernardo S. Franklin · 2017 · Nature · 968 citations

• The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

  T Fernandes-Alnemri, J Wu, J-W Yu · 2007 · Cell Death & Differentiation · 932 citations

• The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

  Bernardo S Franklin, Lukas Bossaller, Dominic De Nardo · 2014 · Nature Immunology · 753 citations

🆕 Influential since 2022

• Didymin Suppresses Microglia Pyroptosis and Neuroinflammation Through the Asc/Caspase-1/GSDMD Pathway Following Experimental Intracerebral Hemorrhage

  Lingui Gu, Mingjiang Sun, Ruihao Li · 2022 · Frontiers in Immunology · 96 citations

• Electromagnetic Scattering Feature (ESF) Module Embedded Network Based on ASC Model for Robust and Interpretable SAR ATR

  Sijia Feng, Kefeng Ji, Fulai Wang · 2022 · IEEE Transactions on Geoscience and Remote Sensing · 82 citations

• Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation

  Inga V. Hochheiser, Heide Behrmann, Gregor Hagelueken · 2022 · Science Advances · 81 citations

• Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells

  Nawar Naseer, Jenna Zhang, Renate Bauer · 2022 · Infection and Immunity · 73 citations

• Exosome-Shuttled miR-672-5p from Anti-Inflammatory Microglia Repair Traumatic Spinal Cord Injury by Inhibiting AIM2/ASC/Caspase-1 Signaling Pathway Mediated Neuronal Pyroptosis

  Zheng Zhou, Cong Li, Tianyi Bao · 2022 · Journal of Neurotrauma · 69 citations

📚 Books worth reading

• The WorksKate Ascher · 2005
• 📕The AscsWalton M. Hancock · 1983
• A Record of the New Books Published: Nov. 1878-Oct. 1879Howard Challen · 1879
• American Society for Composites, Fourth Conference ProceedingsAmer Society Co · 1989
• American Society of Composites, Ninth International Conference ProceedingsAmer Society Co · 1994
• Activated sludge, a comparison of oxygen and air systems · 1983
• The Annual American Catalogue 1886-1900: Being the Full Titles, with Descriptive Notes, of All ...[author not identified] · 1891
• 📕1985-1987 Astoria Senior Center Scrapbook #2Astoria Senior Center · 1985

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

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