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Everything about Pethidine
Opioid analgesic
Pethidine, also known as meperidine and sold under the brand name Demerol among others, is a fully synthetic opioid pain medication of the phenylpiperidine class. Synthesized in 1938 as a potential anticholinergic agent by the German chemist Otto Eisleb, its analgesic properties were first recognized by Otto Schaumann while working for IG Farben, in Germany. Pethidine is the prototype of a large family of analgesics including the pethidine 4-phenylpiperidines, the prodines, bemidones, and others more distant, including diphenoxylate and analogues. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: PethidineA 5-minute orientation
- Skim a recent paper: A novel platform based on CoMn2O4-rGO/1-ethyl-3-methylimidazolium chloride modified carbon paste electrode for voltammetric detection of pethidine in the presence morphine and olanzapineInfluential work since 2022
- Pick up a classic book: Pharmakinetics of pethidine in manThe most-reprinted book on the subject
- Read the landmark paper: THE EVALUATION OF THE ANALGESIC ACTION OF PETHIDINE HYDROCHLORIDE (DEMEROL)Cited 372 times
- Go sideways: TramadolA closely related topic
- Go sideways: NefopamA closely related topic
📖 Definitions
Noun A synthetic compound used as a painkilling drug, especially for women in labor.
🏆 Landmark papers (most cited)
THE EVALUATION OF THE ANALGESIC ACTION OF PETHIDINE HYDROCHLORIDE (DEMEROL)
Childhood cancer, intramuscular vitamin K, and pethidine given during labour.
Ketobemidone, methadone and pethidine are non-competitive N-methyl-d-aspartate (NMDA) antagonists in the rat cortex and spinal cord
Lack of analgesic effect of systemically administered morphine or pethidine on labour pain
Post-operative central hypersensitivity and pain: the pre-emptive value of pethidine for ovariohysterectomy
Comparison of pethidine, buprenorphine and ketoprofen for postoperative analgesia after ovariohysterectomy in the cat
Comparison of ketamine and pethidine in experimental and postoperative pain
Clinical Pharmacokinetics Pethidine
🆕 Influential since 2022
A novel platform based on CoMn2O4-rGO/1-ethyl-3-methylimidazolium chloride modified carbon paste electrode for voltammetric detection of pethidine in the presence morphine and olanzapine
Dual-emission ratiometric fluorescent probe based on N-doped CQDs@UiO-66/PVA nanocomposite hydrogel for quantification of pethidine in human plasma
Voltammetric determination of pethidine in biofluids at a carbon cloth electrode modified by carbon selenide nanofilm
NiO Nanoparticle-decorated graphene oxide nanosheets modified glassy carbon electrode for sensitive electrochemical detection of pethidine
Safety and efficacy of intravenous hydromorphone patient-controlled analgesia versus intramuscular pethidine in acute pancreatitis: An open-label, randomized controlled trial
📚 Books worth reading
- 📕Pharmakinetics of pethidine in manKelvin Kam Chuen Chan · 1975
- 📕Spinal morphine and pethidineStaffan Sjöström · 1987
- 📕Auswirkung vegetativ dämpfender Medikamente (Pethidin, Pethidin mit Levallorphan, Triflupromazin und Dimenhydrinat) auf die Atmung im akuten Stadium schwerer HimschädigungenJohannes Lambert Bröcheler · 1969
- 📕Factors influencing the administration of meperidine (pethidine) to postsurgical patientsLeslie Storozuk · 1978
- 📕Wirkungen von Pethidin auf Ionenkanäle des peripheren Nerven von Xenopus laevisErika Dietlind Koch · 1998
- 📕Präoperative AnxiolyseChristine Kurpiers · 1987
- 📕Amiphenazole (Daptazol®) und seine Wirkung auf die durch Pethidin verursachte AtemdepressionHeinz Stefan Herzka · 1961
- 📕Comparison of analgesic potency and other effects of anileridine and pethidine in manMarjatta Tuominen · 1975
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Tramadol Tramadol, sold under the brand name Tramal among others, is an opioid pain medication and a serotonin–norepinephrine reuptake inhibitor (SNRI) used to…
- Nefopam Nefopam, sold under the brand name Acupan among others, is a centrally acting, non-opioid analgesic medication, with stimulant and sympathomimetic properties…
- Analgesic An analgesic, also called an antalgic, painkiller, or pain reliever, is any member of the group of drugs used for pain management. Analgesics are conceptually…
- Prodine Prodine (trade names Prisilidine and Nisentil) is an opioid analgesic that is an analog of pethidine (meperidine). It was developed in Germany in the late…
- Levallorphan Levallorphan (INN, BAN; USAN levallorphan tartrate; brand names Lorfan, Naloxifan, and Naloxiphan) is an opioid modulator of the morphinan family used…
- Hydromorphone Hydromorphone, also known as dihydromorphinone, and sold under the brand name Dilaudid among others, is a morphinan opioid used to treat moderate to severe…
- Piminodine Piminodine (Alvodine) is an opioid analgesic that is an analogue of pethidine (meperidine). It was used in medicine briefly during the 1960s and 70s, but…
- Tapentadol Tapentadol, sold under the brand names Nucynta and Palexia among others, is a synthetic opioid analgesic with a dual mode of action as a highly selective…