Everything about Pause

🧭 Start here: a 6-step reading path

1. Read the overview: PauseA 5-minute orientation
2. Skim a recent paper: MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targetsInfluential work since 2022
3. Pick up a classic book: SchulgeschichtenThe most-reprinted book on the subject
4. Read the landmark paper: c-Myc Regulates Transcriptional Pause ReleaseCited 1,196 times
5. Go sideways: Dracula (disambiguation)A closely related topic
6. Go sideways: Wild cardA closely related topic

🏆 Landmark papers (most cited)

• c-Myc Regulates Transcriptional Pause Release

  Peter B. Rahl, Charles Y. Lin, Amy C. Seila · 2010 · Cell · 1,196 citations

• Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

  Konstantina Skourti-Stathaki, Nicholas J. Proudfoot, Natalia Gromak · 2011 · Molecular Cell · 833 citations

• BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

  Elodie Hatchi, Konstantina Skourti-Stathaki, Steffen Ventz · 2015 · Molecular Cell · 500 citations

• H3K4me3 regulates RNA polymerase II promoter-proximal pause-release

  Hua Wang, Zheng Fan, Pavel V. Shliaha · 2023 · Nature · 444 citations

• Recent pause in the growth rate of atmospheric CO2 due to enhanced terrestrial carbon uptake

  Trevor F Keenan, I. Colin Prentice, Josep G Canadell · 2016 · Nature Communications · 428 citations

• No pause in the increase of hot temperature extremes

  Sonia I. Seneviratne, Markus G. Donat, Brigitte Mueller · 2014 · Nature Climate Change · 425 citations

• BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure

  Priti Anand, Jonathan D. Brown, Charles Y. Lin · 2013 · Cell · 401 citations

• Brd4 and JMJD6-Associated Anti-Pause Enhancers in Regulation of Transcriptional Pause Release

  Wen Liu, Qi Ma, Kaki Wong · 2013 · Cell · 387 citations

🆕 Influential since 2022

• MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets

  Xintao Qiu, Nadia Boufaied, Tarek Hallal · 2022 · Nature Communications · 171 citations

• First-Line Catheter Ablation of Monomorphic Ventricular Tachycardia in Cardiomyopathy Concurrent With Defibrillator Implantation: The PAUSE-SCD Randomized Trial

  Roderick Tung, Yumei Xue, Minglong Chen · 2022 · Circulation · 166 citations

• The pausing zone and control of RNA polymerase II elongation by Spt5: Implications for the pause-release model

  Nova Fong, Ryan M. Sheridan, Srinivas Ramachandran · 2022 · Molecular Cell · 90 citations

• A ‘print–pause–print’ protocol for 3D printing microfluidics using multimaterial stereolithography

  Yong Tae Kim, Alireza Ahmadianyazdi, Albert Folch · 2023 · Nature Protocols · 78 citations

• SPT6 functions in transcriptional pause/release via PAF1C recruitment

  Yuki Aoi, Avani P. Shah, Sheetal Ganesan · 2022 · Molecular Cell · 78 citations

📚 Books worth reading

• SchulgeschichtenClaudia Lander · 2001
• 📕'Steve' talkingAnn Henshall · 1989
• 📕L'art de la pauseJacquie Barral · 2012
• 📕Pause. Schweigen. StilleRegine Elzenheimer · 2008
• Case Studies of Shorter Working Time (Policy Studies Institute)Michael White · 1981
• 📕Pause!Gabriela Muri · 2004
• Commodore 128 data file programmingMiller, David · 1987

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

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