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Everything about Microsatellite
Repeating sequences of 2–13 base pairs of DNA
A microsatellite is a tract of repetitive DNA that consists of a particular sequence of base pairs repeated a large number of times. Microsatellites occur at thousands of locations within an organism's genome. They have a higher mutation rate than other areas of DNA leading to high genetic diversity. Microsatellites are often referred to as short tandem repeats (STRs) by forensic geneticists and in genetic genealogy, or as simple sequence repeats (SSRs) by plant geneticists. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: MicrosatelliteA 5-minute orientation
- Skim a recent paper: Pembrolizumab versus chemotherapy for microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer (KEYNOTE-177): final analysis of a randomised, open-label, phase 3 studyInfluential work since 2022
- Pick up a classic book: An introduction to forensic geneticsThe most-reprinted book on the subject
- Read the landmark paper: micro ‐ checker : software for identifying and correcting genotyping errors in microsatellite dataCited 9,080 times
- Go sideways: MinisatelliteA closely related topic
- Go sideways: Tandem repeatA closely related topic
📖 Definitions
Noun A miniature satellite.
Noun Any of a group of polymorphic loci in DNA that consist of repeat units of just a few base pairs.
Noun An artificial satellite between 10 and 100 kilograms in mass.
🏆 Landmark papers (most cited)
micro ‐ checker : software for identifying and correcting genotyping errors in microsatellite data
Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer
Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair–Deficient Cancer: Results From the Phase II KEYNOTE-158 Study
Development and characterization of polymorphic microsatellite loci in endangered fern Adiantum reniforme var. sinense
A measure of population subdivision based on microsatellite allele frequencies.
Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study
Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability
Microsatellite Null Alleles and Estimation of Population Differentiation
🆕 Influential since 2022
Pembrolizumab versus chemotherapy for microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer (KEYNOTE-177): final analysis of a randomised, open-label, phase 3 study
First-Line Nivolumab Plus Low-Dose Ipilimumab for Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: The Phase II CheckMate 142 Study
Pembrolizumab in Patients With Microsatellite Instability–High Advanced Endometrial Cancer: Results From the KEYNOTE-158 Study
Pembrolizumab in microsatellite instability high or mismatch repair deficient cancers: updated analysis from the phase II KEYNOTE-158 study
Neoadjuvant Nivolumab Plus Ipilimumab and Adjuvant Nivolumab in Localized Deficient Mismatch Repair/Microsatellite Instability–High Gastric or Esophagogastric Junction Adenocarcinoma: The GERCOR NEONIPIGA Phase II Study
📚 Books worth reading
An introduction to forensic geneticsGoodwin, William Dr., William Goodwin · 2007- 📕MicrosatellitesStella K. Kantartzi · 2013
MicrosatellitesDavid B. Goldstein · 1999- 📕Conifer microsatellite handbookLisa Auckland, Texas A & M University · 2002
Snp And Microsatellite GenotypingAli Hajeer · 2000- 📕Analysis of microsatellite sequences in Scots pineJustyna Nowakowska · 2005
- 📕Microsatellite screening in Pacific halibut (Hippoglossus stenolepis) and a preliminary examination of population structure based on observed DNA variationLorenz Hauser · 2006
- 📕Genetics of differentiation in the marine snail Littorina saxatilis, with consideration of microsatellite genotyping errorsMarina Panova · 2007
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Minisatellite In genetics, a minisatellite is a tract of repetitive DNA in which certain DNA motifs (ranging in length from 10–60 base pairs) are typically repeated…
- Tandem repeat In genetics, tandem repeats occur in DNA when a pattern of one or more nucleotides is repeated and the repetitions are directly adjacent to each other…
- STR analysis Short tandem repeat (STR) analysis is a common molecular biology method used to compare allele repeats at specific loci in DNA between two or more samples…
- Microsatellite instability Microsatellite instability (MSI) is the condition of genetic hypermutability (predisposition to mutation) that results from impaired DNA mismatch repair…
- Genetic marker A genetic marker is a gene or DNA sequence with a known location on a chromosome that can be used to identify individuals or species. It can be described…
- Null allele A null allele is a nonfunctional allele (a variant of a gene) caused by a genetic mutation. Such mutations can cause a complete lack of production of the…
- Restriction fragment length polymorphism In molecular biology, restriction fragment length polymorphism (RFLP) is a technique that exploits variations in homologous DNA sequences, known as polymorphism…
- Amplicon In molecular biology, an amplicon is a piece of DNA that is the source or product of amplification or replication events. It can be formed artificially…